ArticleMicrobial pathogenesis
Gamma-glutamyl transpeptidase has a role in the persistent colonization of the avian gut by Campylobacter jejuni.
Article in Microbial pathogenesis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 92 citations in OpenAlex.
- Transport of the abundant intestinal amino acid glutamine by the enteric pathogenMicrobiology (Reading, England) · 2026Article
- Effects of exogenous protease supplementation of diets containing animal proteins or not on Campylobacter jejuni colonization and on the intestinal microbiota of broiler chickens.Gut pathogens · 2025Article
- Growth rates and metabolic traits differ by diarrhoeal manifestation inJournal of medical microbiology · 2025Article
- Article
- Effects of Hydroxytyrosol Supplementation on Performance, Fat and Blood Parameters of Broiler Chickens.Animals : an open access journal from MDPI · 2023Article
- The glutathione import system satisfies the Staphylococcus aureus nutrient sulfur requirement and promotes interspecies competition.PLoS genetics · 2023Article
- TheMicroorganisms · 2021Article
- Bacterial Gamma-Glutamyl Transpeptidase, an Emerging Biocatalyst: Insights Into Structure-Function Relationship and Its Biotechnological Applications.Frontiers in microbiology · 2021Review
- Antimicrobial Resistance Profiles, Virulence Genes, and Genetic Diversity of ThermophilicFrontiers in microbiology · 2021Article
- Proteomics ofMolecular & cellular proteomics : MCP · 2020Article
- Gamma-glutamyltranspeptidase expression by Helicobacter saguini, an enterohepatic Helicobacter species isolated from cotton top tamarins with chronic colitis.Cellular microbiology · 2019Article
- Comparative genomics analysis to differentiate metabolic and virulence gene potential in gastric versus enterohepatic Helicobacter species.BMC genomics · 2018Article
- Unexpected differential metabolic responses of Campylobacter jejuni to the abundant presence of glutamate and fucose.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Direct Manipulation of T Lymphocytes by Proteins of Gastrointestinal Bacterial Pathogens.Infection and immunity · 2018Review
- Molecular analyses of prostate tumors for diagnosis of malignancy on fine-needle aspiration biopsies.Oncotarget · 2017Article
- Article
- A novel phase variant of the cholera pathogen shows stress-adaptive cryptic transcriptomic signatures.BMC genomics · 2016Article
- γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.Scientific reports · 2016Article
- The Campylobacter jejuni RacRS two-component system activates the glutamate synthesis by directly upregulating γ-glutamyltranspeptidase (GGT).Frontiers in microbiology · 2015Article
- Helicobacter, gamma-glutamyltransferase and cancer: further intriguing connections.World journal of gastroenterology · 2014Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The contribution of gamma-glutamyl transpeptidase (GGT) to Campylobacter jejuni virulence and colonization of the avian gut has been investigated. The presence of the ggt gene in C. jejuni strains directly correlated with the expression of GGT activity as measured by cleavage and transfer of the gamma-glutamyl moiety. Inactivation of the monocistronic ggt gene in C. jejuni strain 81116 resulted in isogenic mutants with undetectable GGT activity; nevertheless, these mutants grew normally in vitro. However, the mutants had increased motility, a 5.4-fold higher invasion efficiency into INT407 cells in vitro and increased resistance to hydrogen peroxide stress. Moreover, the apoptosis-inducing activity of the ggt mutant was significantly lower than that of the parental strain. In vivo studies showed that, although GGT activity was not required for initial colonization of 1-day-old chicks, the enzyme was required for persistent colonization of the avian gut.
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