ArticleGlia2007
Distinct regulation of MHC molecule expression on astrocytes and microglia during viral encephalomyelitis.
Article in Glia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 50 citations in OpenAlex.
- The Impact of Antigen Presentation on BBB Disruption and Neuroinflammation.Physiology (Bethesda, Md.) · 2026Review
- Astrocytic but not Microglial Antigen Presentation Shapes Protective Immunity to Toxoplasma gondii in the Brain.Research square · 2026Article
- Association between Alzheimer's disease and MHC-I antigen processing and presentation pathway: a narrative review.Frontiers in immunology · 2026Review
- Innate Immune Signaling and Role of Glial Cells in Herpes Simplex Virus- and Rabies Virus-Induced Encephalitis.Viruses · 2021Review
- The Role of Astrocytes in CNS Inflammation.Trends in immunology · 2020Review
- Oligodendrocytes that survive acute coronavirus infection induce prolonged inflammatory responses in the CNS.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Protective Functions of Reactive Astrocytes Following Central Nervous System Insult.Frontiers in immunology · 2020Review
- Neuroinflammation During RNA Viral Infections.Annual review of immunology · 2019Review
- Viral Encephalitis and Neurologic Diseases: Focus on Astrocytes.Trends in molecular medicine · 2018Review
- CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis.Brain, behavior, and immunity · 2016Article
- Article
- IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis.Journal of neuroimmunology · 2013Article
- A human astrocytoma cell line is highly susceptible to infection with Trypanosoma cruzi.Memorias do Instituto Oswaldo Cruz · 2013Article
- Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis.Journal of virology · 2013Article
- Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis.Journal of neuroinflammation · 2012Article
- CD4 T cells promote CD8 T cell immunity at the priming and effector site during viral encephalitis.Journal of virology · 2012Article
- IFN-γ signaling to astrocytes protects from autoimmune mediated neurological disability.PloS one · 2012Article
- Modulation of experimental herpes encephalitis-associated neurotoxicity through sulforaphane treatment.PloS one · 2012Article
- Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment.Journal of neuroinflammation · 2011Article
- Memory T cells persisting in the brain following MCMV infection induce long-term microglial activation via interferon-γ.Journal of neurovirology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The potential interplay of glial cells with T cells during viral induced inflammation was assessed by comparing major histocompatibility complex molecule upregulation and retention on astrocytes and microglia. Transgenic mice expressing green fluorescent protein under control of the astrocyte-specific glial fibrillary acidic protein promoter were infected with a neurotropic coronavirus to facilitate phenotypic characterization of astrocytes and microglia using flow cytometry. Astrocytes in the adult central nervous system up-regulated class I surface expression, albeit delayed compared with microglia. Class II was barely detectable on astrocytes, in contrast to potent up-regulation on microglia. Maximal MHC expression in both glial cell types correlated with IFN-gamma levels and lymphocyte accumulation. Despite a decline of IFN-gamma concomitant to virus clearance, MHC molecule expression on glia was sustained. These data demonstrate distinct regulation of both class I and class II expression by microglia and astrocytes in vivo following viral induced inflammation. Furthermore, prolonged MHC expression subsequent to viral clearance implies a potential for ongoing presentation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.