ArticleAmerican journal of respiratory and critical care medicine2007
Spectral karyotyping detects chromosome damage in bronchial cells of smokers and patients with cancer.
Article in American journal of respiratory and critical care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Polyploidy and Senescence of Cancer Cells: Impact of Cell Fusion.Advances in experimental medicine and biology · 2026Review
- Lifetime Smoking History and Risk of Lung Cancer: Results From the Framingham Heart Study.Journal of the National Cancer Institute · 2018Article
- A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas.Oncotarget · 2017Article
- The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer.JCI insight · 2016Article
- Biomarkers of risk to develop lung cancer in the new screening era.Annals of translational medicine · 2016Review
- Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- Genetic stability of bone marrow-derived human mesenchymal stromal cells in the Quantum System.Cytotherapy · 2013Article
- SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling.Journal of molecular medicine (Berlin, Germany) · 2013Article
- A potential probe set of fluorescence in situ hybridization for detection of lung cancer in bronchial brushing specimens.Journal of cancer research and clinical oncology · 2012Article
- Progressive endobronchial premalignancy: marked by original CIN.American journal of respiratory and critical care medicine · 2011Article
- Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension.American journal of respiratory and critical care medicine · 2010Article
- Passenger mutations as a marker of clonal cell lineages in emerging neoplasia.Seminars in cancer biology · 2010Review
- Genetically abnormal circulating cells in lung cancer patients: an antigen-independent fluorescence in situ hybridization-based case-control study.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
- Detection of disease specific sialoglycoconjugate specific antibodies in bronchoalveolar lavage fluid of non-small cell lung cancer patients.Glycoconjugate journal · 2010Article
- Biosafety assessment of site-directed transgene integration in human umbilical cord-lining cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2010Article
- Recurrent genomic gains in preinvasive lesions as a biomarker of risk for lung cancer.PloS one · 2009Article
- Smoking-related genomic signatures in non-small cell lung cancer.American journal of respiratory and critical care medicine · 2008Article
- Update in lung cancer 2007.American journal of respiratory and critical care medicine · 2008Review
- Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer.American journal of respiratory and critical care medicine · 2008Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
rationaleLung cancer is a multistep process that is preceded and often accompanied by molecular cytogenetic lesions in benign bronchial epithelium, the precise character, extent and timing of which are not well defined.
objectivesIn this study we comprehensively defined molecular cytogenetic changes in bronchial cells that may precede lung carcinoma using spectral karyotyping (SKY).
methodsSKY was applied to cultured benign bronchial cells from 43 high-risk smokers without carcinoma, 14 patients with concurrent lung carcinoma, and 14 never-smoker healthy volunteers. MEASUREMENTS AND MAIN
resultsThe proportion of cells displaying numeric or structural anomalies/total number of metaphase cells was calculated for each case and was referred to as the chromosomal abnormality index. Mean chromosomal abnormality indices were 15.8, 10.1, and 0.7% for patients with cancer, high-risk smokers, and never-smokers, respectively. Clonal abnormalities were found in 17 (40%) of the high-risk smokers without carcinoma and 7 (50%) of the patients with carcinoma, but in none of 14 (0%) never-smokers. Chromosomal gains observed by SKY were confirmed in interphase cultured cells or paraffin sections of biopsy specimens by fluorescence in situ hybridization in 11 of 13 cases for which appropriate probes were available. In 6 of 57 high-risk patients or those with carcinoma, identical clonal abnormalities were dispersed at multiple bronchial sites and were admixed with nonclonal cells.
conclusionsClonal and single-cell chromosomal abnormalities are frequent in benign bronchial epithelium during lung carcinogenesis, indicating that chromosomal missegregation and other chromosomal rearrangements occur before overt malignancy.
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