ArticleMolecular immunology2008
P2Y2 nucleotide receptor activation up-regulates vascular cell adhesion molecule-1 [corrected] expression and enhances lymphocyte adherence to a human submandibular gland cell line.
Article in Molecular immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- P2YInternational journal of molecular sciences · 2025Review
- Therapeutic potential for P2YPurinergic signalling · 2023Review
- Xerostomia and Its Cellular Targets.International journal of molecular sciences · 2023Review
- Early Dry Eye Disease Onset in a NOD.H-2h4 Mouse Model of Sjögren's Syndrome.Investigative ophthalmology & visual science · 2022Article
- P2YOral oncology · 2020Article
- P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction.Frontiers in pharmacology · 2020Review
- P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy.The Journal of biological chemistry · 2017Article
- Transcriptional profile of breast muscle in heat stressed layers is similar to that of broiler chickens at control temperature.Genetics, selection, evolution : GSE · 2017Article
- The clearance of dying cells: table for two.Cell death and differentiation · 2016Review
- Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation.Nature communications · 2015Article
- Article
- Purinergic signalling in the gastrointestinal tract and related organs in health and disease.Purinergic signalling · 2014Review
- P2X7 receptor activation induces inflammatory responses in salivary gland epithelium.American journal of physiology. Cell physiology · 2012Article
- Neuroprotective roles of the P2Y(2) receptor.Purinergic signalling · 2012Review
- Resolvin D1 prevents TNF-α-mediated disruption of salivary epithelial formation.American journal of physiology. Cell physiology · 2012Article
- The regulation of focal adhesion complex formation and salivary gland epithelial cell organization by nanofibrous PLGA scaffolds.Biomaterials · 2012Article
- Lipoxin A4 inhibits immune cell binding to salivary epithelium and vascular endothelium.American journal of physiology. Cell physiology · 2012Article
- The role of purinergic signaling on deformation induced injury and repair responses of alveolar epithelial cells.PloS one · 2011Article
- Rat parotid gland cell differentiation in three-dimensional culture.Tissue engineering. Part C, Methods · 2010Article
- P2Y2 nucleotide receptor-mediated responses in brain cells.Molecular neurobiology · 2010Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease that causes salivary and lacrimal gland tissue destruction resulting in impaired secretory function. Although lymphocytic infiltration of salivary epithelium is associated with SS, the mechanisms involved have not been adequately elucidated. Our previous studies have shown that the G protein-coupled P2Y2 nucleotide receptor (P2Y2R) is up-regulated in response to damage or stress of salivary gland epithelium, and in salivary glands of the NOD.B10 mouse model of SS-like autoimmune exocrinopathy. Additionally, we have shown that P2Y2R activation up-regulates vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells leading to the binding of monocytes. The present study demonstrates that activation of the P2Y2R in dispersed cell aggregates from rat submandibular gland (SMG) and in human submandibular gland ductal cells (HSG) up-regulates the expression of VCAM-1. Furthermore, P2Y2R activation mediated the up-regulation of VCAM-1 expression in HSG cells leading to increased adherence of lymphocytic cells. Inhibitors of EGFR phosphorylation and metalloprotease activity abolished P2Y2R-mediated VCAM-1 expression and decreased lymphocyte binding to HSG cells. Moreover, silencing of EGFR expression abolished UTP-induced VCAM-1 up-regulation in HSG cells. These results suggest that P2Y2R activation in salivary gland cells increases the EGFR-dependent expression of VCAM-1 and the binding of lymphocytes, a pathway relevant to inflammation associated with SS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.