ReviewNeuroscience and biobehavioral reviews2007
Activity- and use-dependent plasticity of the developing corticospinal system.
Review in Neuroscience and biobehavioral reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed.
- Home-based early intensive manual therapy in unilateral cerebral palsy under 2 years of age.Pediatric research · 2026Trial
- Early, Intensive, Lower Extremity Rehabilitation Shows Preliminary Efficacy After Perinatal Stroke: Results of a Pilot Randomized Controlled Trial.Neurorehabilitation and neural repair · 2022Trial
- Brain stimulation and constraint for perinatal stroke hemiparesis: The PLASTIC CHAMPS Trial.Neurology · 2016Trial
- Efficacy of baby-CIMT: study protocol for a randomised controlled trial on infants below age 12 months, with clinical signs of unilateral CP.BMC pediatrics · 2014Trial
- Chronic activation of corticospinal tract neurons after pyramidotomy injury enhances neither behavioral recovery nor axonal sprouting.Experimental neurology · 2026Article
- Neurorehabilitation in the 21st Century: New Science, New Strategies, New Expectations.Neurorehabilitation and neural repair · 2026Review
- New Method to Motivate Participation in Daily Life/Everyday Life Activities Using Sensor-Based Smart Application Translating Intention into Action (TIA).Sensors (Basel, Switzerland) · 2026Article
- Transspinal temporal interference stimulation enhances neuroplasticity-associated responses and facilitates motor recovery after spinal cord injury in mice.Frontiers in neuroscience · 2026Article
- Developmental changes in upper limb muscle synergies during throwing: A comparison between preschoolers and schoolers.iScience · 2025Article
- Synaptic imbalance and increased inhibition impair motor function in SMA.Science advances · 2025Article
- Article
- Insights into the dependence of post-stroke motor recovery on the initial corticospinal tract connectivity from a computational model.Journal of neuroengineering and rehabilitation · 2025Article
- Robotic bimanual arm training improves upper limb function in children with hemiparesis: a feasibility study.Frontiers in pediatrics · 2025Article
- Engaging the Lower Extremity via Active Therapy Early (ELEVATE) Is Feasible and May Improve Gross Motor Function in Children with Spastic Bilateral Cerebral Palsy: A Case Series.Physiotherapy Canada. Physiotherapie Canada · 2023Article
- Alterations in cortical morphometry of the contralesional hemisphere in children, adolescents, and young adults with perinatal stroke.Scientific reports · 2023Article
- Protracted development of motor cortex constrains rich interpretations of infant cognition.Trends in cognitive sciences · 2023Review
- Article
- Robotic mapping of motor cortex in children with perinatal stroke and hemiparesis.Human brain mapping · 2022Article
- Motivating Selective Motor Control of Infants at High Risk of Cerebral Palsy Using an In-Home Kicking-Activated Mobile Task: A Pilot Study.Physical therapy · 2022Article
- Bihemispheric developmental alterations in basal ganglia volumes following unilateral perinatal stroke.NeuroImage. Clinical · 2022Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The corticospinal (CS) system, critical for controlling skilled movements, develops during the late prenatal and early postnatal periods in all species examined. In the cat, there is a sequence of development of the mature pattern of terminations of CS tract axons in the spinal gray matter, followed by motor map development of the primary motor cortex. Skilled limb movements begin to be expressed as the map develops. Development of the proper connections between CS axons and spinal neurons in cats depends on CS neural activity and motor behavioral experience during a critical postnatal period. Reversible CS inactivation or preventing limb use produces an aberrant distribution of CS axon terminations and impairs visually guided movements. This altered pattern of CS connections after inactivation in cats resembles the aberrant pattern of motor responses evoked by transcranial magnetic stimulation in hemiplegic cerebral palsy patients. Left untreated in the cat, these impairments do not resolve. We have found that activity-dependent processes can be harnessed in cats to reestablish normal CS connections and function. This finding suggests that aspects of normal CS connectivity and function might some day be restored in hemiplegic cerebral palsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.