ArticleThe EMBO journal2007
Sequence and structure evolved separately in a ribosomal ubiquitin variant.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Tracking of Ubiquitin Signaling through 3.5 Billion Years of Combinatorial Conjugation.International journal of molecular sciences · 2024Review
- Unusually Divergent Ubiquitin Genes and Proteins in Plasmodium Species.Genome biology and evolution · 2023Article
- Ubiquitin and Ubiquitin-Like Proteins and Domains in Ribosome Production and Function: Chance or Necessity?International journal of molecular sciences · 2021Review
- A new gene inventory of the ubiquitin and ubiquitin-like conjugation pathways in Giardia intestinalis.Memorias do Instituto Oswaldo Cruz · 2020Article
- The Ubiquitin Moiety of Ubi1 Is Required for Productive Expression of Ribosomal Protein eL40 inCells · 2019Article
- Computational modeling of Repeat1 region of INI1/hSNF5: An evolutionary link with ubiquitin.Protein science : a publication of the Protein Society · 2016Article
- Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation.Molecular systems biology · 2016Article
- Functions of ribosomal proteins in assembly of eukaryotic ribosomes in vivo.Annual review of biochemistry · 2015Review
- Ubiquitination dynamics in the early-branching eukaryote Giardia intestinalis.MicrobiologyOpen · 2013Article
- Article
- The N-end rule pathway and regulation by proteolysis.Protein science : a publication of the Protein Society · 2011Review
- Ubiquitin and ubiquitin-like proteins in the nucleolus: multitasking tools for a ribosome factory.Genes & cancer · 2010Article
- Overcoming the solubility limit with solubility-enhancement tags: successful applications in biomolecular NMR studies.Journal of biomolecular NMR · 2010Article
- Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Encoded by a multigene family, ubiquitin is expressed in the form of three precursor proteins, two of which are fusions to the ribosomal subunits S27a and L40. Ubiquitin assists in ribosome biogenesis and also functions as a post-translational modifier after its release from S27a or L40. However, several species do not conserve the ribosomal ubiquitin domains. We report here the solution structure of a distant variant of ubiquitin, found at the N-terminus of S27a in Giardia lamblia, referred to as GlUb(S27a). Despite the considerable evolutionary distance that separates ubiquitin from GlUb(S27a), the structure of GlUb(S27a) is largely identical to that of ubiquitin. The variant domain remains attached to S27a and is part of the assembled holoribosome. Thus, conservation of tertiary structure suggests a role of this variant as a chaperone, while conservation of the primary structure--necessary for ubiquitin's function as a post-translational modifier--is no longer required. Based on these observations, we propose a model to explain the origin of the widespread ubiquitin superfold in eukaryotes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.