ArticleJournal of endocrinological investigation2007
Fifteen-year follow-up of thyroid function in lithium patients.
Article in Journal of endocrinological investigation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 76 citations in OpenAlex.
- Incidence of hyperthyroidism in patients with bipolar or schizoaffective disorder with or without lithium: 21-year follow-up from the LiSIE retrospective cohort study.Therapeutic advances in psychopharmacology · 2023Article
- Elevated Thyroxine Concentration and Lithium Intoxication-An Analysis Based on the LiSIE Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- Poorly differentiated thyroid carcinoma arising from a lithium-induced goiter in a patient with schizophrenia: a case report.Thyroid research · 2021Article
- Comparison of thyroid function in different emotional states of drug-naïve patients with bipolar disorder.BMC endocrine disorders · 2021Article
- Lithium-associated hypothyroidism and potential for reversibility after lithium discontinuation: Findings from the LiSIE retrospective cohort study.Journal of psychopharmacology (Oxford, England) · 2020Article
- L-T4 Therapy in the Presence of Pharmacological Interferents.Frontiers in endocrinology · 2020Review
- Trace Elements in Human Nutrition (II) - An Update.International journal of preventive medicine · 2020Review
- The Role of Lithium in Management of Endocrine Tumors-A Comprehensive Review.Frontiers in oncology · 2019Review
- Thyroid and renal tumors in patients treated with long-term lithium: case series from a lithium clinic, review of the literature and international pharmacovigilance reports.International journal of bipolar disorders · 2018Review
- Bipolar disorder and antithyroid antibodies: review and case series.International journal of bipolar disorders · 2016Article
- Lithium side effects and toxicity: prevalence and management strategies.International journal of bipolar disorders · 2016Review
- Autoimmune Thyroiditis in an Adolescent Girl on Lithium.Journal of child and adolescent psychopharmacology · 2016Article
- The impact of Lithium on thyroid function in Chinese psychiatric population.Thyroid research · 2015Article
- Thyrotoxicosis followed by hypothyroidism in a patient on lithium.Mental illness · 2014Article
- A case of severe hypothyroidism causing cardiac tamponade associated with lithium intoxication.Journal of cardiology cases · 2013Article
- Spectrum of lithium induced thyroid abnormalities: a current perspective.Thyroid research · 2013Article
- Lithium-associated thyromegaly: an unusual cause of airway obstruction.Case reports in medicine · 2012Article
- The effects of simvastatin on the serum concentrations of thyroid stimulating hormone and free thyroxine in hypothyroid patients treated with levothyroxine.Iranian journal of medical sciences · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study prospectively the course of clinically relevant thyroid dysfunction in a cohort of patients on long-term lithium treatment.
methodPatients (no.=150) who had undergone a cross-sectional evaluation of their thyroid function in 1989, when they were at different stages of lithium treatment, were followed up for thyroid circulating thyroid antibodies, hypothyroidism, hyperthyroidism, and thyroidectomy, during a further period of lithium exposure of up to 15 yr.
resultsAnnual rates of newly developed circulating thyroid antibodies and hypothyroidism were 1.7 and 1.5%, respectively. Subjects with thyroid antibodies had a higher chance of requiring substitution treatment with levothyroxine for hypothyroidism compared with subjects with no evidence of thyroid antibodies (6.4% annual rate compared to 0.8%; relative risk: 8.4; 95% confidence interval: 2.9-24.0). One case of hyperthyroidism was observed over 976 patient-yr. Three patients underwent thyroidectomy during followup (two for multinodular goiter and one for multicentric papillary carcinoma).
conclusionsLithium may be associated with hypothyroidism in particular in the presence of circulating thyroid antibodies. Incidence of thyroid antibodies is comparable with that reported for the general population. Hyperthyroidism and thyroid cancer are rare.
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