Trial reportCritical care (London, England)2007
Efficacy of and tolerance to mild induced hypothermia after out-of-hospital cardiac arrest using an endovascular cooling system.
Trial report in Critical care (London, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 100 citations in OpenAlex.
- Intravascular versus surface cooling for targeted temperature management after out-of-hospital cardiac arrest - an analysis of the TTM trial data.Critical care (London, England) · 2016Trial
- Nonpharmacologic approach to minimizing shivering during surface cooling: a proof of principle study.Journal of critical care · 2012Trial
- Intravascular cooling for rapid induction of moderate hypothermia in severely head-injured patients: results of a multicenter study (IntraCool).Intensive care medicine · 2009Trial
- Feasibility and Performance of a Gel-Adhesive Pad System for Pediatric Targeted Temperature Management: An Exploratory Analysis of 19 Pediatric Critically Ill Patients.Therapeutic hypothermia and temperature management · 2021Article
- State-of-the-art considerations in post-arrest care.Journal of the American College of Emergency Physicians open · 2020Review
- Effect of Neotype Rectal Mild Hypothermia Therapy on Intestinal Bacterial Translocation in Rats with Hypoxic-Ischemic Brain Damage.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- The application of frequency-domain photoacoustics to temperature-dependent measurements of the Grüneisen parameter in lipids.Photoacoustics · 2018Article
- Adverse drug reactions in therapeutic hypothermia after cardiac arrest.Therapeutic advances in drug safety · 2017Article
- [Is control fever mandatory in severe infections?]Reanimation : journal de la Societe de reanimation de langue francaise · 2016Article
- Thermoregulatory central venous catheter-associated thrombus - echocardiographic detection and novel approach to management.Journal of the Intensive Care Society · 2015Article
- A Head and Neck Support Device for Inducing Local Hypothermia.Journal of medical devices · 2014Article
- Potential role of therapeutic hypothermia in the salvage of traumatic hemorrhagic shock.Critical care (London, England) · 2013Review
- Therapeutic hypothermia for acute neurological injuries.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- EEG monitoring during therapeutic hypothermia in neonates, children, and adults.American journal of electroneurodiagnostic technology · 2011Review
- Assessment of procalcitonin to predict outcome in hypothermia-treated patients after cardiac arrest.Critical care research and practice · 2011Article
- Catheter related venous thrombosis with cooling and warming catheters: two case reports.Cases journal · 2009Article
- Number needed to treat = six: therapeutic hypothermia following cardiac arrest--an effective and cheap approach to save lives.Critical care (London, England) · 2007Article
- Mild induced hypothermia after out-of-hospital cardiac arrest: persisting doubts about patient safety.Critical care (London, England) · 2007Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe evaluated the efficacy of and tolerance to mild therapeutic hypothermia achieved using an endovascular cooling system, and its ability to reach and maintain a target temperature of 33 degrees C after cardiac arrest.
methodsThis study was conducted in the medical-surgical intensive care unit of an urban university hospital. Forty patients admitted to the intensive care unit following out-of-hospital cardiac arrest underwent mild induced hypothermia (MIH). Core temperature was monitored continuously for five days using a Foley catheter equipped with a temperature sensor. Any equipment malfunction was noted and all adverse events attributable to MIH were recorded. Neurological status was evaluated daily using the Pittsburgh Cerebral Performance Category (CPC). We also recorded the mechanism of cardiac arrest, the Simplified Acute Physiologic Score II on admission, standard biological variables, and the estimated time of anoxia. Nosocomial infections during and after MIH until day 28 were recorded.
resultsSix patients (15%) died during hypothermia. Among the 34 patients who completed the period of MIH, hypothermia was steadily maintained in 31 patients (91%). Post-rewarming 'rebound hyperthermia', defined as a temperature of 38.5 degrees C or greater, was observed in 25 patients (74%) during the first 24 hours after cessation of MIH. Infectious complications were observed in 18 patients (45%), but no patient developed severe sepsis or septic shock. The biological changes that occurred during MIH manifested principally as hypokalaemia (< 3.5 mmol/l; in 75% of patients).
conclusionThe intravascular cooling system is effective, safe and allows a target temperature to be reached fairly rapidly and steadily over a period of 36 hours.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.