Evidence map›Paper›PMID 17598168›Full record

SynthesisHuman brain mapping2008

A meta-analytic study of changes in brain activation in depression.

Paul B Fitzgerald, Angela R Laird, Jerome Maller, Zafiris J Daskalakis

Erratum issued 2 registry-linked trialsOpen access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human brain mapping, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 392 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
392citing papers in PubMed, 13 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03040388 completednot on this mapstarted 2017, after this paper: background citation

Predicting Effects and Risk of Relapse Into Depression - The Danish ECT/MRI Project

TypeobservationalSponsorUniversity of CopenhagenRan2017 to 2020Enrolled26ConditionsDepressive Disorder, Depression, Depressive Disorder, Major
NCT04160286 completednot on this mapstarted 2020, after this paper: background citation

The Danish Neuropsychological Study of the Adverse Effects of ECT

TypeobservationalSponsorUniversity of CopenhagenRan2020 to 2024Enrolled73ConditionsDepressive Disorder, Depression, Cognitive Dysfunction, Electroconvulsive TherapyArmsElectroconvulsive therapy
3 · Its place in the literature

Who cites it

392 citing papers in PubMed, 13 syntheses or guidelines pooled it, 905 citations in OpenAlex.

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332 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Paul B FitzgeraldAlfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Commercial Rd Melbourne, Victoria, Australia. paul.fitzgerald@med.monash.edu.au
Angela R Laird
Jerome Maller
Zafiris J Daskalakis
Centre for Addiction and Mental Health · CAMonash Alfred Psychiatry Research centre · AUThe Alfred Hospital · AUThe University of Texas Health Science Center at San Antonio · US

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
Meta-analysis in human brain mappingR56MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2020 to 2020
$543k
NIMH NIH HHS 1 R01 MH074457-01A1NIMH NIH HHS R01 MH074457NIMH NIH HHS R56 MH074457
6 · The paper itself

Abstract

objectiveA large number of studies with considerably variable methods have been performed to investigate brain regions involved in the pathophysiology of major depressive disorder. The aim of this study was to use a quantitative meta-analytic technique to synthesise the results of much of this research.

methodsThree separate quantitative meta-analytical studies were conducted using the Activation Likelihood Estimation technique. Analysis was performed on three types of studies: (1) those conducted at rest comparing brain activation in patients with depression and controls; (2) those involving brain changes following antidepressant treatment; and (3) those comparing brain activation patterns induced by the induction of positive or negative emotion in patients with depression compared with controls.

resultsThere appears to be a complex series of areas of the brain implicated in the pathophysiology of depression although limited overlap was found across imaging paradigms. This included a network of regions including frontal and temporal cortex as well as the insula and cerebellum that are hypoactive in depressed subjects and in which there is increase in activity with treatment. There was a corresponding set of subcortical and limbic regions in which opposite changes were found.

conclusionsThere is limited overlap between the brain regions identified using differing imaging methods. The most consistently identified regions include areas of the anterior cingulate, dorsolateral, medial and inferior prefrontal cortex, insula, superior temporal gyrus, basal ganglia and cerebellum. Further research is required to identify if different imaging methods are identifying complementary networks that are equally involved in the disorder.

Indexed as

Magnetic Resonance ImagingPositron-Emission TomographyTomography, Emission-Computed, Single-PhotonBrainHumansMajor Depressive Disorder

Identifiers

PMID17598168
PMCPMC2873772
OpenAlexW2108337682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.