ReviewJournal of translational medicine2007
Stem cell therapy for autism.
Review in Journal of translational medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01740869 (Autologous Bone Marrow Stem Cells for Children With Autism Spectrum Disorders), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Autologous Bone Marrow Stem Cells for Children With Autism Spectrum Disorders
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD).The Cochrane database of systematic reviews · 2016Pooled it
- Allogeneic Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Autism Spectrum Disorder in Children: Safety Profile and Effect on Cytokine Levels.Stem cells translational medicine · 2019Trial
- Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism.Journal of translational medicine · 2013Trial
- The Neuroimmunology of Autism.Molecular neurobiology · 2025Review
- Transcriptome Study in Sicilian Patients with Autism Spectrum Disorder.Biomedicines · 2024Article
- De novo copy number variations in candidate genomic regions in patients of severe autism spectrum disorder in Vietnam.PloS one · 2024Article
- Cell Therapy Targets for Autism Spectrum Disorders: Hopes, Challenges and Future Directions.Advances in experimental medicine and biology · 2021Article
- Cell Therapy Targets for Autism Spectrum Disorders: Hopes, Challenges and Future Directions.Advances in experimental medicine and biology · 2021Article
- Anti-inflammatory Strategies for Schizophrenia: A Review of Evidence for Therapeutic Applications and Drug Repurposing.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020Article
- Multipotency of mouse trophoblast stem cells.Stem cell research & therapy · 2020Article
- Cell transplantation as a novel therapeutic strategy for autism spectrum disorders: a clinical study.American journal of stem cells · 2020Article
- Neurovascular Organotypic Culture Models Using Induced Pluripotent Stem Cells to Assess Adverse Chemical Exposure Outcomes.Applied in vitro toxicology · 2019Article
- Concise Review: Mesenchymal Stem Cell Therapy for Pediatric Disease: Perspectives on Success and Potential Improvements.Stem cells translational medicine · 2017Review
- The role and potential of umbilical cord blood in an era of new therapies: a review.Stem cell research & therapy · 2015Review
- Anesthesia for stem cell transplantation in autistic children: A prospective, randomized, double-blind comparison of propofol and etomidate following sevoflurane inhalation.Experimental and therapeutic medicine · 2015Article
- Immunophenotypic comparison of heterogenous non-sorted versus sorted mononuclear cells from human umbilical cord blood: a novel cell enrichment approach.Cytotechnology · 2015Article
- Progress of mesenchymal stem cell therapy for neural and retinal diseases.World journal of stem cells · 2014Review
- Autologous bone marrow mononuclear cell therapy for autism: an open label proof of concept study.Stem cells international · 2013Article
- Exploring the enkephalinergic differentiation potential in adult stem cells for cell therapy and drug screening implications.In vitro cellular & developmental biology. Animal · 2012Article
- Isolation of Oct4+, Nanog+ and SOX2- mesenchymal cells from peripheral blood of a diabetes mellitus patient.Human cell · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions whose incidence is reaching epidemic proportions, afflicting approximately 1 in 166 children. Autistic disorder, or autism is the most common form of ASD. Although several neurophysiological alterations have been associated with autism, immune abnormalities and neural hypoperfusion appear to be broadly consistent. These appear to be causative since correlation of altered inflammatory responses, and hypoperfusion with symptology is reported. Mesenchymal stem cells (MSC) are in late phases of clinical development for treatment of graft versus host disease and Crohn's Disease, two conditions of immune dysregulation. Cord blood CD34+ cells are known to be potent angiogenic stimulators, having demonstrated positive effects in not only peripheral ischemia, but also in models of cerebral ischemia. Additionally, anecdotal clinical cases have reported responses in autistic children receiving cord blood CD34+ cells. We propose the combined use of MSC and cord blood CD34+cells may be useful in the treatment of autism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.