Evidence map›Paper›PMID 17597539›Full record

ArticleBMC infectious diseases2007

Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain.

Mark E Wickham, Nat F Brown, John Provias, B Brett Finlay, Brian K Coombes

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  4. Frontiers in microbiology · 2020
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  6. Deletions inHuman vaccines & immunotherapeutics · 2019
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  7. Evidence-based complementary and alternative medicine : eCAM · 2019
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  8. Review
  9. Why does the microbiome affect behaviour?Nature reviews. Microbiology · 2018
    Review
  10. Frontiers in microbiology · 2018
    Article
  11. Review
  12. Antimicrobial agents and chemotherapy · 2017
    Article
  13. Article
  14. Article
  15. Concepts and mechanisms: crossing host barriers.Cold Spring Harbor perspectives in medicine · 2013
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Mark E WickhamMichael Smith Laboratories, University of British Columbia, Vancouver, BC., Canada. m_wickham@mac.com <m_wickham@mac.com>
Nat F Brown
John Provias
B Brett Finlay
Brian K Coombes
Canada's Michael Smith Genome Sciences Centre · CAHamilton Health Sciences · CAMcMaster University · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSalmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported in which to examine infection kinetics and natural dissemination to the brain.

methodsFive mouse lines including C57BL/6, Balb/c, 129S6-Slc11a1tm1Mcg, 129S1/SvImJ, B6.129-Inpp5dtm1Rkh were used in the murine typhoid model to examine the dissemination of systemic Salmonella enterica serovar Typhimurium following oral infection.

resultsWe report data on spontaneous meningitis and brain infection following oral infection of mice with Salmonella enterica serovar Typhimurium.

conclusionThis model may provide a system in which dissemination of bacteria through the central nervous system and the influence of host and bacterial genetics can be queried.

Indexed as

Disease Models, AnimalAdministration, OralAnimalsEncephalitisFemaleMeningitis, BacterialMiceMice, Inbred StrainsSalmonella Infections, AnimalSalmonella typhimurium

Identifiers

PMID17597539
PMCPMC1925087
OpenAlexW2017368108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.