ArticleBMC genomics2007
Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE.
Article in BMC genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation.Peptides · 2022Review
- Coagulopathy is associated with multiple organ damage and prognosis of COVID-19.EXCLI journal · 2021Article
- Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease.Clinical science (London, England : 1979) · 2020Review
- Angiotensin-Converting Enzyme 3 (ACE3) Protects Against Pressure Overload-Induced Cardiac Hypertrophy.Journal of the American Heart Association · 2016Article
- ACE2 - from the renin-angiotensin system to gut microbiota and malnutrition.Microbes and infection · 2013Review
- Angiotensin-converting enzymes play a dominant role in fertility.International journal of molecular sciences · 2013Review
- Emergence and evolution of the renin-angiotensin-aldosterone system.Journal of molecular medicine (Berlin, Germany) · 2012Review
- The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion.Asian journal of andrology · 2011Review
- Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse.PloS one · 2010Article
- Not just angiotensinases: new roles for the angiotensin-converting enzymes.Cellular and molecular life sciences : CMLS · 2010Review
- Losartan chemistry and its effects via AT1 mechanisms in the kidney.Current medicinal chemistry · 2009Review
- Angiotensin-converting enzyme 2 in the brain: properties and future directions.Journal of neurochemistry · 2008Review
- Angiotensin-converting enzyme 2: possible role in hypertension and kidney disease.Current hypertension reports · 2008Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMammalian angiotensin converting enzyme (ACE) plays a key role in blood pressure regulation. Although multiple ACE-like proteins exist in non-mammalian organisms, to date only one other ACE homologue, ACE2, has been identified in mammals.
resultsHere we report the identification and characterisation of the gene encoding a third homologue of ACE, termed ACE3, in several mammalian genomes. The ACE3 gene is located on the same chromosome downstream of the ACE gene. Multiple sequence alignment and molecular modelling have been employed to characterise the predicted ACE3 protein. In mouse, rat, cow and dog, the predicted protein has mutations in some of the critical residues involved in catalysis, including the catalytic Glu in the HEXXH zinc binding motif which is Gln, and ESTs or reverse-transcription PCR indicate that the gene is expressed. In humans, the predicted ACE3 protein has an intact HEXXH motif, but there are other deletions and insertions in the gene and no ESTs have been identified.
conclusionIn the genomes of several mammalian species there is a gene that encodes a novel, single domain ACE-like protein, ACE3. In mouse, rat, cow and dog ACE3, the catalytic Glu is replaced by Gln in the putative zinc binding motif, indicating that in these species ACE3 would lack catalytic activity as a zinc metalloprotease. In humans, no evidence was found that the ACE3 gene is expressed and the presence of deletions and insertions in the sequence indicate that ACE3 is a pseudogene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.