ReviewBrain research reviews2008
Modulation of glutamatergic transmission by sulfated steroids: role in fetal alcohol spectrum disorder.
Review in Brain research reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Untargeted Metabolome Analysis of Alcohol-Exposed Pregnancies Reveals Metabolite Differences That Are Associated with Infant Birth Outcomes.Nutrients · 2022Article
- Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders.Frontiers in endocrinology · 2019Review
- Differentially expressed genes in response to amitraz treatment suggests a proposed model of resistance to amitraz in R. decoloratus ticks.International journal for parasitology. Drugs and drug resistance · 2018Article
- Calcium-engaged Mechanisms of Nongenomic Action of Neurosteroids.Current neuropharmacology · 2017Review
- Mutation of the Dyslexia-Associated Gene Dcdc2 Enhances Glutamatergic Synaptic Transmission Between Layer 4 Neurons in Mouse Neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Could folic acid influence growth cone motility during the development of neural connectivity?Neurogenesis (Austin, Tex.) · 2016Article
- Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo.Journal of cell science · 2015Article
- Pregnenolone sulfate as a modulator of synaptic plasticity.Psychopharmacology · 2014Review
- Pregnenolone sulfate: from steroid metabolite to TRP channel ligand.Molecules (Basel, Switzerland) · 2013Review
- Neurosteroids, stress and depression: potential therapeutic opportunities.Neuroscience and biobehavioral reviews · 2013Review
- Modulation by pregnenolone sulfate of filtering properties in the hippocampal trisynaptic circuit.Hippocampus · 2012Article
- Neurosteroid influences on sensitivity to ethanol.Frontiers in endocrinology · 2012Article
- Activation of steroid-sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats.Journal of neurochemistry · 2011Article
- Fetal alcohol spectrum disorders and abnormal neuronal plasticity.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2011Review
- Molecular imaging of σ receptors: synthesis and evaluation of the potent σ1 selective radioligand [18F]fluspidine.European journal of nuclear medicine and molecular imaging · 2011Article
- Pregnenolone sulfate increases glutamate release at neonatal climbing fiber-to-Purkinje cell synapses.Neuroscience · 2011Article
- Focus on: neurotransmitter systems.Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2011Review
- Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis.Brain : a journal of neurology · 2010Article
- Repeated third trimester-equivalent ethanol exposure inhibits long-term potentiation in the hippocampal CA1 region of neonatal rats.Alcohol (Fayetteville, N.Y.) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
It is well established that sulfated steroids regulate synaptic transmission by altering the function of postsynaptic neurotransmitter receptors. In recent years, evidence from several laboratories indicates that these agents also regulate glutamatergic synaptic transmission at the presynaptic level in an age-dependent manner. In developing neurons, pregnenolone sulfate (PREGS) increases the probability of glutamate release, as evidenced by an increase in the frequency of AMPA receptor-mediated miniature excitatory postsynaptic currents and a decrease in paired-pulse facilitation. In hippocampal slices from postnatal day 3-5 rats, this effect is mediated by an increase in Ca(2+) levels in the axonal terminal that depends on presynaptic NMDA receptors. This is followed by delayed potentiation of postsynaptic AMPA receptor currents. Importantly, depolarization of postsynaptic neurons, inhibition of hydroxysteroid sulfatase activity and acute exposure to ethanol mimics the effect of exogenous PREGS application. This developmental form of synaptic plasticity cannot be observed in slices from rats older than postnatal day 6, when presynaptic NMDA receptors are no longer expressed in CA1 hippocampal region. Both in the CA1 hippocampal region and the dentate gyrus of more mature rats, PREGS, dehydroepiandrosterone sulfate and hydroxysteroid sulfatase inhibitors increase paired-pulse facilitation, without affecting basal glutamate release probability. This effect depends on activation of sigma(1)-like receptors and G(i/o) and involves a target in the release machinery that is downstream of residual Ca(2+). These presynaptic actions of sulfated steroids could play important roles in physiological processes ranging from synapse maturation to learning and memory, as well as pathophysiological conditions such as fetal alcohol spectrum disorder.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.