ArticleMolecular immunology2008
The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility.
Article in Molecular immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- CD59 Regulation by SOX2 Is Required for Epithelial Cancer Stem Cells to Evade Complement Surveillance.Stem cell reports · 2017Article
- Mouse Cd59b but not Cd59a is upregulated to protect cells from complement attack in response to inflammatory stimulation.Genes and immunity · 2015Article
- CD59 underlines the antiatherosclerotic effects of C-phycocyanin on mice.BioMed research international · 2013Article
- The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury.The American journal of pathology · 2011Article
- Interplay between REST and nucleolin transcription factors: a key mechanism in the overexpression of genes upon increased phosphorylation.Nucleic acids research · 2010Article
- The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice.Molecular immunology · 2010Article
- Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex.Circulation research · 2009Article
- Generation and phenotyping of mCd59a and mCd59b double-knockout mice.American journal of hematology · 2009Article
- Absence of the complement regulatory molecule CD59a leads to exacerbated neuropathology after traumatic brain injury in mice.Journal of neuroinflammation · 2009Article
- Modulation of CD59 expression by restrictive silencer factor-derived peptides in cancer immunotherapy for neuroblastoma.Cancer research · 2008Article
Corrections and comments
- Retraction · 2014-01-03Investigation by Company/Institution · Manipulation of Images ·
- Retracted
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In mouse, genes encoding complement regulators CD55 and CD59 have been duplicated. The first described form of CD59, CD59a, is broadly distributed in mouse tissues, while the later identified CD59b was originally described as testis specific. Subsequent studies have been contradictory, some reporting widespread and abundant expression of CD59b. Resolution of the distribution patterns of the CD59 isoforms is important for interpretation of disease studies utilising CD59 knockout mice. Here we have performed a comprehensive distribution study of the CD59 isoforms at the mRNA and protein levels. These data confirm that expression of CD59b is essentially restricted to adult testis; trace expression in other tissues is a consequence of contamination with blood cells, shown previously to express CD59b at low level. In testis, onset of expression of CD59b coincided with puberty and was predominant on the spermatozoal acrosome. Ligation of CD59b, but not CD59a, markedly reduced spermatozoal motility, suggesting a specific role in reproductive function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.