ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
State-dependent modulation of amygdala inputs by dopamine-induced enhancement of sodium currents in layer V entorhinal cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Review
- Active Dendrites and Local Field Potentials: Biophysical Mechanisms and Computational Explorations.Neuroscience · 2022Review
- Dopamine D2 Receptor-Mediated Modulation of Rat Retinal Ganglion Cell Excitability.Neuroscience bulletin · 2020Article
- The role of negative conductances in neuronal subthreshold properties and synaptic integration.Biophysical reviews · 2017Review
- Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Repeated restraint stress exerts different impact on structure of neurons in the lateral and basal nuclei of the amygdala.Neuroscience · 2013Article
- Effects of repeated stress on excitatory drive of basal amygdala neurons in vivo.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- In vivo voltage-dependent influences on summation of synaptic potentials in neurons of the lateral nucleus of the amygdala.Neuroscience · 2012Article
- Dopamine and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells.The Journal of comparative neurology · 2012Article
- Functional maps within a single neuron.Journal of neurophysiology · 2012Review
- Distance- and activity-dependent modulation of spike back-propagation in layer V pyramidal neurons of the medial entorhinal cortex.Journal of neurophysiology · 2011Article
- Projection-specific neuromodulation of medial prefrontal cortex neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Interaction between the entorhinal cortex (EC) and basolateral amygdala (BLA) may be a fundamental component in the consolidation of many forms of affective memory, such as inhibitory avoidance. Dopamine (DA) in the EC is necessary for, and may facilitate, this form of learning. This effect of DA on affective behaviors may be accomplished in part through modulation of amygdala inputs. Although it is known that DA can modulate neuronal activity in the EC, it is not known whether DA modulates inputs from the BLA. In this study, we used in vitro patch-clamp recordings and Ca2+ imaging of layer V neurons in the rat lateral EC to determine whether DA modulates the integration of inputs from the BLA and the mechanism for this modulation. We found that DA exerted actions that depended on the neuronal state. Near resting membrane potentials, DA suppressed integration of inputs, whereas at depolarized potentials, DA enhanced integration. DA enhanced the integration by a D2-mediated enhancement of Na+ currents, via phospholipase C. These experiments demonstrate that DA can exert actions in the EC that depend on the membrane voltage. This effect of DA may affect a wide range of inputs. Functionally, by enhancement of amygdala inputs that arrive in concert with other inputs, or during depolarized states, DA can facilitate the impact of affect on memory in a subset of conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.