ArticleJournal of virology2007
In vivo and in vitro intragenomic rearrangement of TT viruses.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Maternal infection during pregnancy and the risk of childhood cancer: a systematic review and meta-analysis.BMC medicine · 2026Pooled it
- Maternal Infection in Pregnancy and Childhood Leukemia: A Systematic Review and Meta-analysis.The Journal of pediatrics · 2020Pooled it
- Anellovirus constraint from 2 to 6 months postpartum followed by betatorquevirus and gammatorquevirus dominance in serum and milk.Journal of virology · 2025Article
- Torque Teno Virus: Lights and Shades.Viruses · 2025Review
- Anelloviruses versus human immunity: how do we control these viruses?FEMS microbiology reviews · 2024Review
- Human Anelloviruses: Influence of Demographic Factors, Recombination, and Worldwide Diversity.Microbiology spectrum · 2023Article
- Evolution of anelloviruses from a circovirus-like ancestor through gradual augmentation of the jelly-roll capsid protein.Virus evolution · 2023Article
- Human anelloviruses: diverse, omnipresent and commensal members of the virome.FEMS microbiology reviews · 2020Review
- Redondoviridae, a Family of Small, Circular DNA Viruses of the Human Oro-Respiratory Tract Associated with Periodontitis and Critical Illness.Cell host & microbe · 2019Article
- Viral metagenomics revealed novel betatorquevirus species in pediatric inpatients with encephalitis/meningoencephalitis from Ghana.Scientific reports · 2019Article
- High-throughput sequencing exclusively identified a novel Torque teno virus genotype in serum of a patient with fatal fever.Virologica Sinica · 2014Article
- A human torque teno virus encodes a microRNA that inhibits interferon signaling.PLoS pathogens · 2013Article
- Article
- Phylogenetic analysis of Torque Teno Virus genome from Pakistani isolate and incidence of co-infection among HBV/HCV infected patients.Virology journal · 2012Article
- Serological profile of torque teno sus virus species 1 (TTSuV1) in pigs and antigenic relationships between two TTSuV1 genotypes (1a and 1b), between two species (TTSuV1 and -2), and between porcine and human anelloviruses.Journal of virology · 2012Article
- Rescue of a porcine anellovirus (torque teno sus virus 2) from cloned genomic DNA in pigs.Journal of virology · 2012Article
- Epstein-Barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis.PloS one · 2012Article
- Recombination in eukaryotic single stranded DNA viruses.Viruses · 2011Review
- The diversity of torque teno viruses: in vitro replication leads to the formation of additional replication-competent subviral molecules.Journal of virology · 2011Article
- Torque teno virus 10 isolated by genome amplification techniques from a patient with concomitant chronic lymphocytic leukemia and polycythemia vera.Molecular medicine (Cambridge, Mass.) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The in vitro replication of the Torque teno virus (TT virus) tth8 full-length genome and particle formation in a Hodgkin's lymphoma-derived cell line after transfection with cloned viral DNA were demonstrated. Analyses of the transcription patterns of tth8 and tth7 TT virus isolates in a number of lymphoma and T-cell leukemia cell lines indicated differential additional splicing events and intragenomic rearrangement generating open reading frames which could not be deducted from the genomic sequence. We also demonstrated the presence of rearranged TT virus genomes in vivo in sera taken from pregnant mothers whose children later developed childhood leukemia, as well as sera from control mothers. Control experiments using religated cloned genomic tth8 DNA mixed with cellular DNA did not result in such subviral molecules. These subviral isolates ranged from 172 bp to full-length TT virus genomes. Possible in vivo selection for specific rearranged molecules was indicated by the presence of one isolate (561 bp) in 11 serum samples. It remains to be clarified whether selected rearranged subviral components resulting from specific TT virus types may contribute to the initiation of disease. These data demonstrate new features of TT viruses suggesting possible similarities to plant viruses of the family Geminiviridae, as well as raise questions about the documented plurality and diversity of anelloviruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.