ArticleMolecular biology reports2008
Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts.
Article in Molecular biology reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Meta-analysis for the Association of Apolipoprotein E ε2/ε3/ε4 Polymorphism with Coronary Heart Disease.Chinese medical journal · 2015Pooled it
- Meta-analysis of APOE ε2/ε3/ε4 polymorphism and cerebral infarction.Journal of neural transmission (Vienna, Austria : 1996) · 2013Pooled it
- Article
- A global view of the genetic basis of Alzheimer disease.Nature reviews. Neurology · 2023Review
- Prevalence of Null Genotypes of Glutathione S-Transferase T1 (GSTT1) and M1 (GSTM1) in Seven Iranian Populations.Iranian journal of public health · 2015Article
- Susceptibility to Colorectal Cancer and Two Genetic Polymorphisms of XRCC4.Pathology oncology research : POR · 2015Article
- Lack of an association between left-handedness and APOE polymorphism in a large sample of adults: results of the Czech HAPIEE study.Laterality · 2013Article
- Genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) in selected populations of Afghanistan.Molecular biology reports · 2012Article
- The frequency and distribution of thiopurine S-methyltransferase alleles in south Iranian population.Molecular biology reports · 2012Article
- Prevalence of G6721T polymorphism of XRCC7 in an Iranian population.EXCLI journal · 2012Article
- Protective effect of the APOE-e3 allele in Alzheimer's disease.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Apolipoprotein A5-1131T>C polymorphism, but not APOE genotypes, increases susceptibility for dyslipidemia in children and adolescents.Molecular biology reports · 2011Article
- Association between N142D genetic polymorphism of GSTO2 and susceptibility to colorectal cancer.Molecular biology reports · 2011Article
- Disease gene interaction pathways: a potential framework for how disease genes associate by disease-risk modules.PloS one · 2011Article
- Does the geographical gradient of ApoE4 allele exist in China? A systemic comparison among multiple Chinese populations.Molecular biology reports · 2011Article
- Alzheimer's disease: diagnostics, prognostics and the road to prevention.The EPMA journal · 2010Article
- Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations.Molecular biology reports · 2010Article
- A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease.Molecular biology reports · 2009Article
- Frequency of cystathionine beta-synthase 844INS68 polymorphism in Southern Iran.Molecular biology reports · 2009Article
- Genetic counseling in southern Iran: consanguinity and reason for referral.Journal of genetic counseling · 2008Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApolipoprotein E (apoE) with three major alleles E2, E3 and E4 is one of the critical genes in lipid metabolism. Common apoE alleles are in association with an increase in risk for central nervous and cardiovascular diseases such as Alzheimer's disease, dementia, multiple sclerosis, atherosclerosis, coronary heart disease, hyperlipoproteinemia and stroke. ApoE3 is known as the most frequent allele in all populations, while association of apoE gene polymorphism with reported diseases have mostly been related to other two major alleles especially apoE4.
objectiveTo determine of apoE alleles frequencies in Southern Iran and comparison of those frequencies with other populations.
methodsDNA was extracted from the whole blood of 198 healthy unrelated candidates from population of Fars Province, Southern Iran, for apoE genotyping who were checked up by a physician. The frequencies of apoE alleles were compared with other populations by chi(2) test.
resultsThe frequencies of E2, E3 and E4 were 0.063, 0.886 and 0.051 respectively. These values were similar to those reported from populations of Kuwait, Oman, Lebanon, India, Turkey, Greece, Spain, Sardinia Islands of Italy and two Iranian populations but were different from South of Italy and Caucasians in other Europe regions, American, American-Indian, African, East Asian and Saudi populations (P < 0.05).
conclusionThe frequency of E4 allele as a genetic risk factor for some multifactorial diseases in the population of Southern Iran is in the lowest reported amounts in the world. Iranian population has Caucasoid origin but differs from some Caucasian populations in Europe and America. The results of present study are in agreement with the historical evidences which show admixture of Iranian population with other populations and some studies based on genetic polymorphisms in the population of Southern Iran.
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