ArticleBMC microbiology2007
Structure and evolution of a proviral locus of Glyptapanteles indiensis bracovirus.
Article in BMC microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Innexin DNA-binding domains regulateiScience · 2025Article
- Genome, host genome integration, and gene expression inFrontiers in microbiology · 2023Article
- The Complete Genome ofJournal of virology · 2022Article
- Genome-Wide Patterns of Bracovirus Chromosomal Integration into Multiple Host Tissues during Parasitism.Journal of virology · 2021Article
- Bracoviruses recruit host integrases for their integration into caterpillar's genome.PLoS genetics · 2021Article
- Shrinking of repeating unit length in leucine-rich repeats from double-stranded DNA viruses.Archives of virology · 2021Article
- Genomic architecture of endogenous ichnoviruses reveals distinct evolutionary pathways leading to virus domestication in parasitic wasps.BMC biology · 2020Article
- Detecting bracoviral orthologs distribution in five tsetse fly species and the housefly genomes.BMC research notes · 2020Article
- Genomic and Proteomic Analyses Indicate that Banchine and Campoplegine Polydnaviruses Have Similar, if Not Identical, Viral Ancestors.Journal of virology · 2015Article
- Recurrent Domestication by Lepidoptera of Genes from Their Parasites Mediated by Bracoviruses.PLoS genetics · 2015Article
- Polydnaviruses: From discovery to current insights.Virology · 2015Review
- Widespread genome reorganization of an obligate virus mutualist.PLoS genetics · 2014Article
- Article
- Article
- Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- When parasitic wasps hijacked viruses: genomic and functional evolution of polydnaviruses.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- The bracovirus genome of the parasitoid wasp Cotesia congregata is amplified within 13 replication units, including sequences not packaged in the particles.Journal of virology · 2013Article
- Adaptive selection on bracovirus genomes drives the specialization of Cotesia parasitoid wasps.PloS one · 2013Article
- Evolutionary mechanisms driving the evolution of a large polydnavirus gene family coding for protein tyrosine phosphatases.BMC evolutionary biology · 2012Article
- Evolutionary genomics of Colias Phosphoglucose Isomerase (PGI) introns.Journal of molecular evolution · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBracoviruses (BVs), a group of double-stranded DNA viruses with segmented genomes, are mutualistic endosymbionts of parasitoid wasps. Virus particles are replication deficient and are produced only by female wasps from proviral sequences integrated into the wasp genome. Virus particles are injected along with eggs into caterpillar hosts, where viral gene expression facilitates parasitoid survival and therefore perpetuation of proviral DNA. Here we describe a 223 kbp region of Glyptapanteles indiensis genomic DNA which contains a part of the G. indiensis bracovirus (GiBV) proviral genome.
resultsEighteen of ~24 GiBV viral segment sequences are encoded by 7 non-overlapping sets of BAC clones, revealing that some proviral segment sequences are separated by long stretches of intervening DNA. Two overlapping BACs, which contain a locus of 8 tandemly arrayed proviral segments flanked on either side by ~35 kbp of non-packaged DNA, were sequenced and annotated. Structural and compositional analyses of this cluster revealed it exhibits a G+C and nucleotide composition distinct from the flanking DNA. By analyzing sequence polymorphisms in the 8 GiBV viral segment sequences, we found evidence for widespread selection acting on both protein-coding and non-coding DNA. Comparative analysis of viral and proviral segment sequences revealed a sequence motif involved in the excision of proviral genome segments which is highly conserved in two other bracoviruses.
conclusionContrary to current concepts of bracovirus proviral genome organization our results demonstrate that some but not all GiBV proviral segment sequences exist in a tandem array. Unexpectedly, non-coding DNA in the 8 proviral genome segments which typically occupies ~70% of BV viral genomes is under selection pressure suggesting it serves some function(s). We hypothesize that selection acting on GiBV proviral sequences maintains the genetic island-like nature of the cluster of proviral genome segments described herein. In contrast to large differences in the predicted gene composition of BV genomes, sequences that appear to mediate processes of viral segment formation, such as proviral segment excision and circularization, appear to be highly conserved, supporting the hypothesis of a single origin for BVs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.