ArticleMetabolic brain disease2008
Effect of ageing on Ca2+ uptake via NMDA receptors into barrel cortex slices of spontaneously hypertensive rats.
Article in Metabolic brain disease, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 6 citations in OpenAlex.
- Calcium homeostasis in aging neurons.Frontiers in genetics · 2012Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the normal ageing cortex of the brain there is a group of dying neurons with shrinking dendritic trees and a group of surviving neurons with expanding dendritic trees. The ageing process affects neurotransmitter systems, including glutamate neurons and NMDA receptors. Calcium is an important signaling molecule. It enters brain cells through NMDA receptors and voltage-gated calcium channels. Since NMDA receptors play an important role in brain plasticity, calcium uptake through NMDA receptors can be used as a measure of brain activity. This study therefore sought to determine the effect of ageing on NMDA-stimulated Ca(2+) uptake into barrel cortex slices of Spontaneously Hypertensive Rats (SHR) compared to control Wistar-Kyoto rats (WKY). Young rats (prepuberty, 4-6 weeks) and adult rats (14-16 weeks) were used in the study. The results show a significant decrease in NMDA-stimulated Ca(2+) uptake in adult rats compared to their young litter-mates. It can be concluded that ageing negatively affects NMDA-stimulated Ca(2+) uptake into barrel cortex slices of SHR and WKY.
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