ArticleEuropean journal of nutrition2007
Dietary omega-3-polyunsaturated fatty acids prevent the development of metastases of colon carcinoma in rat liver.
Article in European journal of nutrition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- An interpretable machine learning model for predicting early liver metastasis after pancreatic cancer surgery.BMC cancer · 2025Article
- Review
- ω-3 Polyunsaturated Fatty Acids on Colonic Inflammation and Colon Cancer: Roles of Lipid-Metabolizing Enzymes Involved.Nutrients · 2020Review
- Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer.Frontiers in pharmacology · 2016Review
- Prevention of diabetes-promoted colorectal cancer by (n-3) polyunsaturated fatty acids and (n-3) PUFA mimetic.Oncotarget · 2014Article
- Regulating surgical oncotaxis to improve the outcomes in cancer patients.Surgery today · 2014Review
- Hepatic steatosis is associated with lower incidence of liver metastasis from colorectal cancer.International journal of colorectal disease · 2013Article
- Dietary ω -3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer.BioMed research international · 2013Review
- The omega-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of PGE2-dependent cell motility.British journal of pharmacology · 2012Article
- Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial.Nutrition & metabolism · 2011Article
- Omega-3 fatty acid inhibition of prostate cancer progression to hormone independence is associated with suppression of mTOR signaling and androgen receptor expression.Nutrition and cancer · 2011Article
- Decreased polyunsaturated Fatty Acid content contributes to increased survival in human colon cancer.Journal of oncology · 2009Article
- PROUD: effects of preoperative long-term immunonutrition in patients listed for liver transplantation.Trials · 2007Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFish oil consisting of omega-3 polyunsaturated fatty acids (PUFA) seems to reduce the incidence of colon cancer. The effect of PUFAs on metastasis of colon carcinoma is still unclear.
aimThe study was designed to examine the effects of a diet rich in omega-3-PUFAs on a model of colorectal metastasis.
methodsThirty animals (WAG/Rij) were randomly assigned to receive an omega-3 diet or a control diet to evaluate their effect on tumor growth. The target male rats (WAG/Rij) were fed a diet containing 15% omega-3-fatty acids three days before and 28 days after intervention and the control rats received 15% coconut oil at the same time points. CC 531 cells, a moderately differentiated colon adenocarcinoma, were injected into the spleen of each rat. After 28 days of diet, animals were sacrificed. The tumor growth was evaluated macroscopically and microscopically in liver tissue. The tissue was examined after immunostaining and the use of monoclonal antibodies.
resultsPUFAs decreased the index of tumor load from 1.54 in the controls to 0.79 in the treatment group (P = 0.036). While 69.2% of the control animals were tumor positive, only 21.4% of the target animals showed tumor after omega-3-fatty acid (P < 0.05).
conclusionWe could show that omega-3-fatty acids may decrease malignant metastatic tumor growth in the liver.
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