ArticleHuman genetics2007
Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin.
Article in Human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pooled it
- An embedded method for gene identification problems involving unwanted data heterogeneity.Human genomics · 2019Article
- Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases.Human genetics · 2015Article
- Article
- Polymorphisms influencing prostate-specific antigen concentration may bias genome-wide association studies on prostate cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
- A genetic-based approach to personalized prostate cancer screening and treatment.Current opinion in urology · 2015Review
- The prostate cancer susceptibility variant rs2735839 near KLK3 gene is associated with aggressive prostate cancer and can stratify gleason score 7 patients.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men.Clinical chemistry · 2014Article
- Personalized prostate specific antigen testing using genetic variants may reduce unnecessary prostate biopsies.The Journal of urology · 2013Article
- Androgen metabolism and JAK/STAT pathway genes and prostate cancer risk.Cancer epidemiology · 2012Article
- Single nucleotide polymorphism barcoding to evaluate oral cancer risk using odds ratio-based genetic algorithms.The Kaohsiung journal of medical sciences · 2012Article
- Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels.Carcinogenesis · 2011Article
- Association of prostate cancer risk Loci with disease aggressiveness and prostate cancer-specific mortality.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia.European journal of human genetics : EJHG · 2011Article
- Genetic correction of PSA values using sequence variants associated with PSA levels.Science translational medicine · 2010Article
- Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics using novel sumLINK and sumLOD analyses.The Prostate · 2010Article
- Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Article
- A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33.Human genetics · 2010Article
- Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry.The Prostate · 2009Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two of the classical kallikrein genes KLK3 and KLK2 on 19q13.4 are plausible candidates in prostate cancer susceptibility. They are expressed almost exclusively in prostate tissue. We have performed a comprehensive analysis of association of variants in these two genes with prostate cancer among men of European descent using a tagging SNP approach. Thirteen SNPs selected from the HapMap database were analyzed in a sample of 596 histologically verified prostate cancer cases and 567 ethnically matched controls. Five SNPs showed significant association at single marker level. Linkage disequilibrium (LD) analysis revealed four LD blocks. We performed a haplotype analysis within each LD block. A major haplotype in block 1 that contains the first two significantly associated SNPs was significantly underrepresented in the prostate cancer cases; a second haplotype in block 3 also showed significant frequency differences between cases and controls. Four of the studied SNPs show positive associations with serum PSA levels. A structure analysis revealed no population stratification in our samples that could have confounded the association results. These findings suggest a plausible role of kallikrein gene variants in the etiology of prostate cancer among men of European ancestry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.