Trial reportChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2007
Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas.
Trial report in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Intracystic bleomycin for cystic craniopharyngiomas in children.The Cochrane database of systematic reviews · 2016Pooled it
- Phase II study of peginterferon alpha-2b for patients with unresectable or recurrent craniopharyngiomas: a Pediatric Brain Tumor Consortium report.Neuro-oncology · 2020Trial
- Trends in treatment and outcomes of pediatric craniopharyngioma, 1975-2011.Neuro-oncology · 2013Trial
- Evaluating temozolomide for pediatric adamantinomatous craniopharyngiomas using microspheroid-based drug screening.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Adamantinomatous craniopharyngioma stone: is it a tumor?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Targeted Treatment of Pediatric Craniopharyngioma: Lesson Learnt After 20-Year Experience with Intracystic Interferon Alpha.Advances and technical standards in neurosurgery · 2025Article
- Feasibility, tolerability, and first experience of intracystic treatment with peginterferon alfa-2a in patients with cystic craniopharyngioma.Frontiers in oncology · 2024Article
- Adamantinomatous craniopharyngioma: evolution in the management.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- An update on multimodal management of craniopharyngioma in children.Frontiers in oncology · 2023Article
- Chemo-immunoablation of solid tumors: A new concept in tumor ablation.Frontiers in immunology · 2022Review
- Treatment of Cystic Craniopharyngiomas: An Update.Advances and technical standards in neurosurgery · 2022Article
- Adamantinomatous craniopharyngioma in the molecular age and the potential of targeted therapies: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- Canadian Pediatric Neuro-Oncology Standards of Practice.Frontiers in oncology · 2020Article
- Intratumoral recombinant human interferon alpha-2a and vincristine combination therapy in canine transmissible venereal tumour.Veterinary medicine and science · 2018Article
- Pediatric Craniopharyngiomas: A Primer for the Skull Base Surgeon.Journal of neurological surgery. Part B, Skull base · 2018Review
- Intracystic interferon-alpha in pediatric craniopharyngioma patients-reply.Neuro-oncology · 2017Article
- Intracystic interferon-alpha in pediatric craniopharyngioma patients.Neuro-oncology · 2017Article
- Intracystic interferon-alpha in pediatric craniopharyngioma patients: an international multicenter assessment on behalf of SIOPE and ISPN.Neuro-oncology · 2017Article
- Insights into the infiltrative behavior of adamantinomatous craniopharyngioma in a new xenotransplant mouse model.Brain pathology (Zurich, Switzerland) · 2015Article
- Intracavitary brachytherapy using stereotactically applied phosphorus-32 colloid for treatment of cystic craniopharyngiomas in 53 patients.Journal of neuro-oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to verify whether intracystic injections of alpha-Interferon (IFN-alpha) in cystic craniopharyngiomas were able to reduce the tumor by activating the Fas apoptotic pathway. MATERIALS AND
methodsTwenty-one patients with cystic craniopharyngiomas treated at the Pediatric Oncology Institute (IOP/GRAACC) of Federal University of São Paulo were submitted to intracystic chemotherapy with IFN-alpha. The tumor sizes of all patients were monitored and the apoptotic factor soluble FasL (sFasL) concentration was determined by ELISA (enzyme-linked immunosorbent assay) in tumor fluid samples from eight patients.
resultsThere was a complete reduction in 11 patients, a partial response in seven, and a minor response in three patients. The concentration of sFasL was increased in all the eight patients examined concomitantly with the tumor size reduction.
conclusionsOur data demonstrated that the IFN-alpha was able to induce Fas-mediated apoptosis together with a reduction in the tumor size; such an observation may suggest the importance to investigate still unexplored mechanisms to be exploited in craniopharyngioma therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.