ReviewInternational orthopaedics2007
Prostaglandin E(2) receptors in bone formation.
Review in International orthopaedics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Attenuation of orthodontically induced inflammatory root resorption by using low-intensity pulsed ultrasound as a therapeutic modality- a systematic review.BMC oral health · 2024Pooled it
- Timing of ibuprofen use and bone mineral density adaptations to exercise training.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Trial
- Article
- Modern Approaches and Emerging Biological Therapies to Treat Fracture Nonunion.Pharmaceutics · 2025Review
- Low pH induces amiloride-sensitive expression of leukemia inhibitory factor in endometrial cells.The Journal of reproduction and development · 2025Article
- Factors Associated with Non-Unions of Fifth Metatarsal Fractures.The archives of bone and joint surgery · 2025Article
- FXR Activation Accelerates Early Phase of Osteoblast Differentiation Through COX-2-PGEMolecules (Basel, Switzerland) · 2024Article
- Short-Term Celecoxib Promotes Bone Formation without Compromising Cefazolin Efficacy in an Early Orthopaedic Device-Related Infection: Evidence from a Rat Model.Antibiotics (Basel, Switzerland) · 2024Article
- Impact of Bone Morphogenetic Protein 7 and Prostaglandin receptors on osteoblast healing and organization of collagen.PloS one · 2024Article
- Causality between Ankylosing Spondylitis and osteoarthritis in European ancestry: a bidirectional Mendelian randomization study.Frontiers in immunology · 2024Article
- Osteocyte-mediated mechanical response controls osteoblast differentiation and function.Frontiers in physiology · 2024Review
- Complete form of pachydermoperiostosis with good initial response to etoricoxib: A case report.Clinical case reports · 2023Article
- P2X7Rs: new therapeutic targets for osteoporosis.Purinergic signalling · 2023Review
- Murine Animal Models in Osteogenesis Imperfecta: The Quest for Improving the Quality of Life.International journal of molecular sciences · 2022Review
- Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence.Endocrine reviews · 2022Review
- Article
- Identification of Biomarkers That Modulate Osteogenic Differentiation in Mesenchymal Stem Cells Related to Inflammation and Immunity: A Bioinformatics-Based Comprehensive Study.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Review
- Immune mechanism of low bone mineral density caused by ankylosing spondylitis based on bioinformatics and machine learning.Frontiers in genetics · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prostaglandins, PGE(2) in particular, have diverse actions on various organs, including inflammation, bone healing, bone formation, embryo implantation, induction of labour and vasodilatation, among others. However, systemic side effects have limited their clinical utility. The pharmacological activities of PGE(2) are mediated through four G protein-coupled receptor subtypes, EP1-EP4. Recent studies have shown that EP2 and EP4 receptors play important roles in regulating bone formation and resorption. EP2 and EP4 receptor-selective agonists have been shown to stimulate local or systemic bone formation, augment bone mass and accelerate the healing of fractures or bone defects in animal models upon local or systemic administration, thus, potentially offering new therapeutic options for enhancing bone formation and bone repair in humans. This review will focus on the studies related to bone formation and bone healing in the EP receptor knockout (KO) mice and the EP2 or EP4 receptor-selective agonist treated animal models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.