ArticleTrials2007
Outcome measurement in clinical trials for Ulcerative Colitis: towards standardisation.
Article in Trials, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03656627 (Safety, Activity, and Pharmacology of Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Disease), which is not on this map. Cited by 44 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety, Activity, and Pharmacology of Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Disease
Who cites it
44 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Patient-centred outcomes are under-reported in the critical care burns literature: a systematic review.Trials · 2022Pooled it
- The Efficacy of Probiotics, Prebiotic Inulin-Type Fructans, and Synbiotics in Human Ulcerative Colitis: A Systematic Review and Meta-Analysis.Nutrients · 2019Pooled it
- Endoscopic scoring indices for evaluation of disease activity in ulcerative colitis.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- Clinical effectiveness of selective granulocyte, monocyte adsorptive apheresis with the Adacolumn device in ulcerative colitis.Digestive diseases and sciences · 2010Pooled it
- Health-Related Quality of Life and Work-Related Outcomes for Patients With Mild-to-Moderate Ulcerative Colitis and Remission Status Following Short-Term and Long-Term Treatment With Multimatrix Mesalamine: A Prospective, Open-Label Study.Inflammatory bowel diseases · 2018Trial
- Nutritional Indices as Non-Invasive Biomarkers: PNI and CONUT Scores Predict Clinical and Endoscopic Activity in Ulcerative Colitis.Nutrients · 2026Article
- Add-on multiple submucosal injections of the RNA oligonucleotide GUT-1 to anti-TNF antibody treatment in patients with moderate-to-severe ulcerative colitis: an open-label, proof-of concept study.Inflammation and regeneration · 2024Article
- Effectiveness of Tofacitinib in Ulcerative Proctitis Compared to Left Sided Colitis and Pancolitis.Digestive diseases and sciences · 2024Article
- Construct validity of EQ-5D-5L among patients with inflammatory bowel disease-a study based on real-world data from the Swedish Inflammatory Bowel Disease Registry.Journal of patient-reported outcomes · 2024Article
- How subjective well-being, patient-reported clinical improvement (PROMs) and experience of care (PREMs) relate in an acute psychiatric care setting?European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Development of a Novel Ulcerative Colitis Endoscopic Mayo Score Prediction Model Using Machine Learning.Gastro hep advances · 2023Article
- A longitudinal model for the Mayo Clinical Score and its sub-components in patients with ulcerative colitis.Journal of pharmacokinetics and pharmacodynamics · 2022Article
- What to measure in biliary atresia research: study protocol for developing a core outcome set.BMJ open · 2021Article
- Evaluating the optimum number of biopsies to assess histological inflammation in ulcerative colitis: a retrospective cohort study.Alimentary pharmacology & therapeutics · 2020Article
- Performance of a Deep Learning Model vs Human Reviewers in Grading Endoscopic Disease Severity of Patients With Ulcerative Colitis.JAMA network open · 2019Article
- Clostridium difficile isolated from faecal samples in patients with ulcerative colitis.BMC infectious diseases · 2019Article
- Effect of Irritable Bowel Syndrome on Sleep Quality and Quality of Life of Inflammatory Bowel Disease in Clinical Remission.International journal of preventive medicine · 2019Article
- Colonic epithelial mTORC1 promotes ulcerative colitis through COX-2-mediated Th17 responses.Mucosal immunology · 2018Article
- Towards global consensus on core outcomes for hidradenitis suppurativa research: an update from the HISTORIC consensus meetings I and II.The British journal of dermatology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical trials on novel drug therapies require clear criteria for patient selection and agreed definitions of disease remission. This principle has been successfully applied in the field of rheumatology where agreed disease scoring systems have allowed multi-centre collaborations and facilitated audit across treatment centres. Unfortunately in ulcerative colitis this consensus is lacking. Thirteen scoring systems have been developed but none have been properly validated. Most trials choose different endpoints and activity indices, making comparison of results from different trials extremely difficult. International consensus on endoscopic, clinical and histological scoring systems is essential as these are the key components used to determine entry criteria and outcome measurements in clinical trials on ulcerative colitis. With multiple new therapies under development, there is a pressing need for consensus to be reached.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.