ArticleMolecular medicine (Cambridge, Mass.)
Paraoxonase 1 response to a high-fat diet: gender differences in the factors involved.
Article in Molecular medicine (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Paraoxonase (PON1) polymorphisms Q192R and L55M are not associated with human longevity: A meta-analysis.Zeitschrift fur Gerontologie und Geriatrie · 2016Pooled it
- PON1 and Mediterranean Diet.Nutrients · 2015Pooled it
- Paraoxonases as metabolic and signaling modulators: prospects for therapeutic and preventive implications.npj metabolic health and disease · 2026Review
- Gender-effect on the contractile properties of skeletal muscle in streptozotocin-induced diabetic rats.Journal of musculoskeletal & neuronal interactions · 2018Article
- Bis(4,4'-dimethyl-2,2'-bipyridine)oxidovanadium(IV) Sulfate Dehydrate: Potential Candidate for Controlling Lipid Metabolism?BioMed research international · 2017Article
- Sex differences in obesity-induced hypertension and vascular dysfunction: a protective role for estrogen in adipose tissue inflammation?American journal of physiology. Regulatory, integrative and comparative physiology · 2016Review
- Species differences in paraoxonase mediated hydrolysis of several organophosphorus insecticide metabolites.Journal of toxicology · 2015Article
- Functionally defective high-density lipoprotein and paraoxonase: a couple for endothelial dysfunction in atherosclerosis.Cholesterol · 2013Review
- Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations.Disease markers · 2013Article
- Hormonal and chemical regulation of paraoxonases in mice.The Journal of pharmacology and experimental therapeutics · 2012Article
- Modulation of paraoxonases during infectious diseases and its potential impact on atherosclerosis.Lipids in health and disease · 2012Review
- Isocaloric intake of a high-fat diet modifies adiposity and lipid handling in a sex dependent manner in rats.Lipids in health and disease · 2011Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diets consumed in industrialized countries are rich in fat and increase the incidence of atherosclerosis, a process reported to be influenced by gender. Considering the anti-atherogenic role attributed to serum Paraoxonase 1 (PON1) activity, and given the pro-atherogenic effects described for saturated fatty acids (SFA), as opposed to the beneficial ones conferred to monounsaturated fatty acids (MUFA), the aim of this study was to investigate the response of male and female rat serum PON1 activity and its related factors to a high-fat (HF), hypercaloric diet (fat representing 55.2% of the energy) containing similar amounts of SFA and MUFA. The HF diet feeding did not alter total body weight, but increased adiposity. Nevertheless, and in spite of the increased adiposity, the HF diet did not entail a more pro-inflammatory serum adipokine or lipid profile or increased lipid peroxidation. Paraoxonase activity was reduced in both male and female HF fed rats, due to a reduction of PON1 mRNA levels in males and to a reduced stability and/or number of HDL particles responsible for PON1 transport in females. Both the maintenance of body weight and the MUFA content in the diet would be among the factors responsible for the attenuation of the negative effects usually related to excessive fat intake and for the reduction in PON activity, whose antioxidant activity would be less necessary in this situation.
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