ArticleMolecular medicine (Cambridge, Mass.)
Expression of the neural stem cell markers NG2 and L1 in human angiomyolipoma: are angiomyolipomas neoplasms of stem cells?
Article in Molecular medicine (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Trial
- Tuberous sclerosis complex.Nature reviews. Disease primers · 2026Review
- Review of hTERT-Immortalized Cells: How to Assess Immortality and Confirm Identity.International journal of molecular sciences · 2024Review
- Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model Via Induction of Apoptosis.Molecular cancer therapeutics · 2023Article
- Review
- Chemical Biology Screening Identifies a Vulnerability to Checkpoint Kinase Inhibitors in TSC2-Deficient Renal Angiomyolipomas.Frontiers in oncology · 2022Article
- The Codon 72Molecular cancer research : MCR · 2019Article
- Histopathologic characteristics and immunotypes of perivascular epithelioid cell tumors (PEComa).International journal of clinical and experimental pathology · 2019Article
- mTORC1 Inhibition Is an Effective Treatment for Sporadic Renal Angiomyolipoma.Kidney international reports · 2018Article
- Notch transactivates Rheb to maintain the multipotency of TSC-null cells.Nature communications · 2017Article
- Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells.Nature communications · 2017Article
- Peroxisome proliferator-activated receptor gamma (PPARγ) is central to the initiation and propagation of human angiomyolipoma, suggesting its potential as a therapeutic targetEMBO molecular medicine · 2017Article
- Pericyte-fibroblast transition promotes tumor growth and metastasis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Co-option of pre-existing vascular beds in adipose tissue controls tumor growth rates and angiogenesis.Oncotarget · 2016Article
- Article
- Expression of CD44 and CD29 by PEComa cells suggests their possible origin of mesenchymal stem cells.International journal of clinical and experimental pathology · 2015Article
- Enrichment of the embryonic stem cell reprogramming factors Oct4, Nanog, Myc, and Sox2 in benign and malignant vascular tumors.BMC clinical pathology · 2015Article
- Theranostic impact of NG2/CSPG4 proteoglycan in cancer.Theranostics · 2015Review
- Shedding of NG2 by MMP-13 attenuates anoikis.DNA and cell biology · 2014Article
- Evidence for pericyte origin of TSC-associated renal angiomyolipomas and implications for angiotensin receptor inhibition therapy.American journal of physiology. Renal physiology · 2014Article
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Angiomyolipomas are benign tumors of the kidney which express phenotypes of smooth muscle, fat, and melanocytes. These tumors appear with increased frequency in the autosomal dominant disorder tuberous sclerosis and are the leading cause of morbidity in adults with tuberous sclerosis. While benign, these tumors are capable of provoking life threatening hemorrhage and replacement of the kidney parenchyma, resulting in renal failure. The histogenesis of these tumors is currently unclear, although currently, we believe these tumors arise from "perivascular epithelioid cells" of which no normal counterpart has been convincingly demonstrated. Recently, stem cell precursors have been recognized that can give rise to smooth muscle and melanocytes. These precursors have been shown to express the neural stem cell marker NG2 and L1. In order to determine whether angiomyolipomas, which exhibit smooth muscle and melanocytic phenotypes, express NG2 and L1, we performed immunocytochemistry on a cell line derived from a human angiomyolipoma, and found that these cells are uniformly positive. Immunohistochemistry of human angiomyolipoma specimens revealed uniform staining of tumor cells, while renal cell carcinomas revealed positivity only of angiogenic vessels. These results support a novel histogenesis of angiomyolipoma as a defect in differentiation of stem cell precursors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.