ArticleBritish journal of pharmacology2007
Functional interactions between presynaptic NMDA receptors and metabotropic glutamate receptors co-expressed on rat and human noradrenergic terminals.
Article in British journal of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Near-random connections support top-down feature-based attentional modulations in early sensory cortex.PLoS computational biology · 2025Article
- Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators.Neuropharmacology · 2022Article
- Synaptosomes and Metamodulation of Receptors.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Noradrenaline in the aging brain: Promoting cognitive reserve or accelerating Alzheimer's disease?Seminars in cell & developmental biology · 2021Review
- Presynaptic release-regulating NMDA receptors in isolated nerve terminals: A narrative review.British journal of pharmacology · 2021Review
- Zerumbone Modulates αFrontiers in pharmacology · 2020Article
- Presynaptic Release-regulating Metabotropic Glutamate Receptors: An Update.Current neuropharmacology · 2020Review
- Multineuromodulator measurements across fronto-striatal network areas of the behaving macaque using solid-phase microextraction.Journal of neurophysiology · 2019Article
- Immuno-Pharmacological Characterization of Presynaptic GluN3A-Containing NMDA Autoreceptors: Relevance to Anti-NMDA Receptor Autoimmune Diseases.Molecular neurobiology · 2019Article
- Acute Functional Adaptations in Isolated Presynaptic Terminals Unveil Synaptosomal Learning and Memory.International journal of molecular sciences · 2019Review
- Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology.Neuropharmacology · 2019Article
- Presynaptic mGlu1 Receptors Control GABAFrontiers in molecular neuroscience · 2018Article
- Metabotropic glutamate receptor 5 as a potential target for smoking cessation.Psychopharmacology · 2017Review
- CCL5-Glutamate Cross-Talk in Astrocyte-Neuron Communication in Multiple Sclerosis.Frontiers in immunology · 2017Review
- CXCR4 and NMDA Receptors Are Functionally Coupled in Rat Hippocampal Noradrenergic and Glutamatergic Nerve Endings.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Article
- Presynaptic Release-Regulating mGlu1 Receptors in Central Nervous System.Frontiers in pharmacology · 2016Review
- Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory.The Behavioral and brain sciences · 2016Article
- Anti-allodynic Efficacy of NMDA Antagonist Peptide and Noradrenaline Alone and in Combination in Rodent Neuropathic Pain Model.The Korean journal of pain · 2015Article
- Nicotinic modulation of glutamate receptor function at nerve terminal level: a fine-tuning of synaptic signals.Frontiers in pharmacology · 2015Review
- MicroRNA-19b associates with Ago2 in the amygdala following chronic stress and regulates the adrenergic receptor beta 1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeElectrophysiological studies described potentiation of NMDA receptor function by metabotropic glutamate receptors (mGluRs) of group I occurring postsynaptically. Since release-enhancing NMDA receptors exist on noradrenergic terminals and group I mGluRs have recently been identified on these nerve endings, we have investigated if NMDA receptor-mGluR interactions also can occur at the presynaptic level. EXPERIMENTAL APPROACH: Rat hippocampus and human neocortex synaptosomes were labelled with [(3)H]noradrenaline and superfused with mGluR agonists and antagonists. NMDA-evoked [(3)H]noradrenaline release was produced by removal of external Mg(2+) or by simultaneous application of NMDA and AMPA in Mg(2+)-containing solutions. KEY
resultsThe mGluR1/5 agonist 3,5-DHPG, inactive on its own, potentiated both the release of [(3)H]noradrenaline elicited by AMPA/NMDA/glycine and that evoked by NMDA/glycine following Mg(2+) removal. The effect of 3,5-DHPG on the AMPA/NMDA/glycine-induced release was insensitive to the mGluR1 antagonist CPCCOEt, but it was abolished by the mGluR5 antagonist MPEP; moreover, it was potentiated by the mGluR5 positive allosteric modulator DFB. When NMDA receptors were activated by Mg(2+) removal, both mGluR5 and mGluR1 contributed to the evoked release, the mGluR-mediated release being blocked only by CPCCOEt and MPEP in combination. Experiments with human neocortex synaptosomes show NMDA receptor-mGluR interactions qualitatively similar to those observed in rodents. CONCLUSIONS AND IMPLICATIONS: Group I mGluRs, both of the mGluR1 and mGluR5 subtypes, co-localize with NMDA receptors on noradrenergic terminals of rat hippocampus and human neocortex. Depending on the mode of activation, NMDA receptors exert differential permissive roles on the activation of presynaptic mGluR1 and mGluR5.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.