Evidence map›Paper›PMID 17592288›Full record

Trial reportAnnals of surgery2007

Effect of enteral nutrition and synbiotics on bacterial infection rates after pylorus-preserving pancreatoduodenectomy: a randomized, double-blind trial.

Nada Rayes, Daniel Seehofer, Tom Theruvath, Martina Mogl, Jan M Langrehr, Natascha C Nüssler, Stig Bengmark, Peter Neuhaus

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00688311 (Pilot Trial of a Synbiotic in HIV+ Patients), which is not on this map. Cited by 72 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 12 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00688311 nacompletednot on this mapstarted 2008, after this paper: background citation

Pilot Trial of a Synbiotic in HIV+ Patients

TypeinterventionalSponsorUniversity of California, DavisRan2008 to 2009Enrolled34ConditionsHIV InfectionArmsSynbiotic 2000, Placebo
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 12 syntheses or guidelines pooled it, 222 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Postoperative nutritional support after pancreaticoduodenectomy in adults.The Cochrane database of systematic reviews · 2025
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Probiotics and Synbiotics Decrease Postoperative Sepsis in Elective Gastrointestinal Surgical Patients: a Meta-Analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016
    Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Nada RayesDepartment of General, Visceral and Transplant Surgery, Charité Campus Virchow, Humboldt University, Berlin, Germany. nada.rayes@charite.de
Daniel Seehofer
Tom Theruvath
Martina Mogl
Jan M Langrehr
Natascha C Nüssler
Stig Bengmark
Peter Neuhaus
Humboldt-Universität zu Berlin · DECharité - Universitätsmedizin Berlin · DERoyal College of Surgeons of England · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePatients undergoing pancreas resection carry several risk factors for nosocomial bacterial infections. Pre- and probiotics (synbiotics) are potentially useful for prevention of these infections. SUMMARY BACKGROUND DATA: First trials in patients following major abdominal surgery including liver transplantation using one Lactobacillus (LAB) and one fiber showed significant reduction of infection rates and reduced length of antibiotic therapy compared with a control group. The present study was designed to analyze whether a combination of different LAB and fibers would further improve outcome.

methodsA prospective randomized monocentric double-blind trial was undertaken in 80 patients following pylorus-preserving pancreatoduodenectomy (PPPD). All patients received enteral nutrition immediately postoperatively. One group (A) received a composition of 4 LAB and 4 fibers, and another group (B) received placebo (fibers only) starting the day before surgery and continuing for 8 days. Thirty-day infection rate, length of hospital stay, duration of antibiotic therapy, noninfectious complications, and side effects were recorded.

resultsThe incidence of postoperative bacterial infections was significantly lower with LAB and fibers (12.5%) than with fibers only (40%). In addition, the duration of antibiotic therapy was significantly shorter in the latter group. Fibers and LAB were well tolerated.

conclusionEarly enteral nutrition supplemented with a mixture of LAB and fibers reduces bacterial infection rates and antibiotic therapy following PPPD.

Indexed as

Bacterial InfectionsAnti-Infective AgentsDouble-Blind MethodEnteral NutritionFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPancreaticoduodenectomyPostoperative CareProbioticsProspective StudiesPylorusSurvival RateAnti-Infective Agents

Identifiers

PMID17592288
PMCPMC1899208
OpenAlexW2065651045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.