ArticleThe Journal of cell biology2007
Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- The antagonistic relationship between apoptosis and polyploidy in development and cancer.Seminars in cell & developmental biology · 2024Review
- Non-Canonical Roles of Apoptotic Caspases in the Nervous System.Frontiers in cell and developmental biology · 2022Review
- A novel function for Rab1 and Rab11 during secretory granule maturation.Journal of cell science · 2021Article
- Programmed cell death reshapes the central nervous system during metamorphosis in insects.Current opinion in insect science · 2021Review
- Ecdysone controlled cell and tissue deletion.Cell death and differentiation · 2020Review
- Tango7 regulates cortical activity of caspases during reaper-triggered changes in tissue elasticity.Nature communications · 2017Article
- HDAC Inhibitors Disrupt Programmed Resistance to Apoptosis DuringG3 (Bethesda, Md.) · 2017Article
- Mutants forG3 (Bethesda, Md.) · 2017Article
- Article
- The Steroid Hormone 20-Hydroxyecdysone Promotes the Cytoplasmic Localization of Yorkie to Suppress Cell Proliferation and Induce Apoptosis.The Journal of biological chemistry · 2016Article
- Control of apoptosis by Drosophila DCAF12.Developmental biology · 2016Article
- Analysis of mitochondrial structure and function in the Drosophila larval musculature.Mitochondrion · 2016Review
- Induction of rapid and selective cell necrosis in Drosophila using Bacillus thuringiensis Cry toxin and its silkworm receptor.BMC biology · 2015Article
- Cell death in development: Signaling pathways and core mechanisms.Seminars in cell & developmental biology · 2015Review
- Ecdysone-induced receptor tyrosine phosphatase PTP52F regulates Drosophila midgut histolysis by enhancement of autophagy and apoptosis.Molecular and cellular biology · 2014Article
- INO80-dependent regression of ecdysone-induced transcriptional responses regulates developmental timing in Drosophila.Developmental biology · 2014Article
- A steroid-controlled global switch in sensitivity to apoptosis during Drosophila development.Developmental biology · 2014Article
- Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability.Development (Cambridge, England) · 2014Article
- Translational control by the DEAD Box RNA helicase belle regulates ecdysone-triggered transcriptional cascades.PLoS genetics · 2012Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A pulse of the steroid hormone ecdysone triggers the destruction of larval salivary glands during Drosophila metamorphosis through a transcriptional cascade that converges on reaper (rpr) and head involution defective (hid) induction, resulting in caspase activation and cell death. We identify the CREB binding protein (CBP) transcriptional cofactor as essential for salivary gland cell death. We show that CBP acts 1 d before the onset of metamorphosis in apparent response to a mid-third instar ecdysone pulse, when CBP is necessary and sufficient for down-regulation of the Drosophila inhibitor of apoptosis 1 (DIAP1). It is only after DIAP1 levels are reduced that salivary glands become competent to die through rpr/hid-mediated cell death. Before this time, high levels of DIAP1 block salivary gland cell death, even in the presence of ectopic rpr expression. This study shows that naturally occurring changes in inhibitor of apoptosis levels can be critical for regulating cell death during development. It also provides a molecular mechanism for the acquisition of competence in steroid signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.