ArticleInfection and immunity2007
Comparative role of immunoglobulin A in protective immunity against the Bordetellae.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Review
- Generating enhanced mucosal immunity againstFrontiers in immunology · 2023Article
- Gastrointestinal helminths increaseeLife · 2022Article
- The efficacy of a 2,4-diaminoquinazoline compound as an intranasal vaccine adjuvant to protect against influenza A virus infection in vivo.Journal of microbiology (Seoul, Korea) · 2022Article
- Reduction of endotoxicity in Bordetella bronchiseptica by lipid A engineering: Characterization of lpxL1 and pagP mutants.Virulence · 2021Article
- Modeling Immune Evasion and Vaccine Limitations by Targeted Nasopharyngeal Bordetella pertussis Inoculation in Mice.Emerging infectious diseases · 2021Article
- A Marker-FreeVaccines · 2019Article
- Intranasal acellular pertussis vaccine provides mucosal immunity and protects mice fromNPJ vaccines · 2019Article
- IL-17-dependent SIgA-mediated protection against nasal Bordetella pertussis infection by live attenuated BPZE1 vaccine.Mucosal immunology · 2018Article
- The Role of Mucosal Immunity in Pertussis.Frontiers in immunology · 2018Review
- Horizontally acquired divergent O-antigen contributes to escape from cross-immunity in the classical bordetellae.BMC evolutionary biology · 2013Article
- Impact of IgA constant domain on HIV-1 neutralizing function of monoclonal antibody F425A1g8.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Lack of cross-protection against Bordetella holmesii after pertussis vaccination.Emerging infectious diseases · 2012Article
- Network model of immune responses reveals key effectors to single and co-infection dynamics by a respiratory bacterium and a gastrointestinal helminth.PLoS computational biology · 2012Article
- Article
- Immune regulation of a chronic bacteria infection and consequences for pathogen transmission.BMC microbiology · 2010Article
- The O antigen is a critical antigen for the development of a protective immune response to Bordetella parapertussis.Infection and immunity · 2009Article
- Article
- Bordetella pertussis infection or vaccination substantially protects mice against B. bronchiseptica infection.PloS one · 2009Article
- Evidence for horizontal gene transfer of two antigenically distinct O antigens in Bordetella bronchiseptica.Infection and immunity · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The genus Bordetella includes a group of closely related mammalian pathogens that cause a variety of respiratory diseases in a long list of animals (B. bronchiseptica) and whooping cough in humans (B. pertussis and B. parapertussis). While past research has examined how these pathogens are eliminated from the lower respiratory tract, the host factors that control and/or clear the bordetellae from the upper respiratory tract remain unclear. We hypothesized that immunoglobulin A (IgA), the predominant mucosal antibody isotype, would have a protective role against these mucosal pathogens. IgA(-/-) mice were indistinguishable from wild-type mice in their control and clearance of B. pertussis or B. parapertussis, suggesting that IgA is not crucial to immunity to these organisms. However, naïve and convalescent IgA(-/-) mice were defective in reducing the numbers of B. bronchiseptica in the upper respiratory tract compared to wild-type controls. Passively transferred serum from convalescent IgA(-/-) mice was not as effective as serum from convalescent wild-type mice in clearing this pathogen from the tracheae of naive recipient mice. IgA induced by B. bronchiseptica infection predominantly recognized lipopolysaccharide-containing O-antigen, and antibodies against O-antigen were important to bacterial clearance from the trachea. Since an IgA response contributes to the control of B. bronchiseptica infection of the upper respiratory tract, immunization strategies aimed at inducing B. bronchiseptica-specific IgA may be beneficial to preventing the spread of this bacterium among domestic animal populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.