ArticleMolecular and cellular biology2007
Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- G-CSF drives autoinflammation in APLAID.Nature immunology · 2023Article
- PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.Nature communications · 2017Article
- Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity.Clinical reviews in allergy & immunology · 2017Review
- Mechanisms of central tolerance for B cells.Nature reviews. Immunology · 2017Review
- Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.The Journal of experimental medicine · 2015Article
- VprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- PLAID: a Syndrome of Complex Patterns of Disease and Unique Phenotypes.Journal of clinical immunology · 2015Review
- Rac-mediated Stimulation of Phospholipase Cγ2 Amplifies B Cell Receptor-induced Calcium Signaling.The Journal of biological chemistry · 2015Article
- Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling.Nature reviews. Immunology · 2014Review
- Balancing Proliferation with Igκ Recombination during B-lymphopoiesis.Frontiers in immunology · 2014Review
- B cell receptor editing in tolerance and autoimmunity.Annals of the New York Academy of Sciences · 2011Review
- Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.Nature immunology · 2009Article
- Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling.Nature reviews. Immunology · 2009Review
- A role for interferon regulatory factor 4 in receptor editing.Molecular and cellular biology · 2008Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Phospholipase Cgamma2 (PLCgamma2) is critical for pre-B-cell receptor (pre-BCR) and BCR signaling. Current studies discovered that PLCgamma2-deficient mice had reduced immunoglobulin lambda (Iglambda) light-chain usage throughout B-cell maturation stages, including transitional type 1 (T1), transitional type 2 (T2), and mature follicular B cells. The reduction of Iglambda rearrangement by PLCgamma2 deficiency was not due to specifically increased apoptosis or decreased proliferation of mutant Iglambda+ B cells, as lack of PLCgamma2 exerted a similar effect on apoptosis and proliferation of both Iglambda+ and Igkappa+ B cells. Moreover, PLCgamma2-deficient IgHEL transgenic B cells exhibited an impairment of antigen-induced receptor editing among both the endogenous lambda and kappa loci in vitro and in vivo. Importantly, PLCgamma2 deficiency impaired BCR-induced expression of IRF-4 and IRF-8, the two transcription factors critical for lambda and kappa light-chain rearrangements. Taken together, these data demonstrate that the PLCgamma2 signaling pathway plays a role in activation of light-chain loci and contributes to receptor editing.
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Registered trials
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