ArticleNucleic acids research2007
Alternatively spliced isoforms of the human elk-1 mRNA within the 5' UTR: implications for ELK-1 expression.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Decoding sORF translation - from small proteins to gene regulation.RNA biology · 2016Review
- What Is the Impact of mRNA 5' TL Heterogeneity on Translational Start Site Selection and the Mammalian Cellular Phenotype?Frontiers in genetics · 2016Review
- The effect of heterogeneous Transcription Start Sites (TSS) on the translatome: implications for the mammalian cellular phenotype.BMC genomics · 2015Article
- The impact of the phosphomimetic eIF2αS/D on global translation, reinitiation and the integrated stress response is attenuated in N2a cells.Nucleic acids research · 2015Article
- An AUG codon conserved for protein function rather than translational initiation: the story of the protein sElk1.PloS one · 2014Article
- The current status of vertebrate cellular mRNA IRESs.Cold Spring Harbor perspectives in biology · 2013Review
- Alternative splicing within the elk-1 5' untranslated region serves to modulate initiation events downstream of the highly conserved upstream open reading frame 2.Molecular and cellular biology · 2012Article
- Dimer formation and conformational flexibility ensure cytoplasmic stability and nuclear accumulation of Elk-1.Nucleic acids research · 2011Article
- The translational response of the human mdm2 gene in HEK293T cells exposed to rapamycin: a role for the 5'-UTRs.Nucleic acids research · 2011Article
- Human SHBG mRNA translation is modulated by alternative 5'-non-coding exons 1A and 1B.PloS one · 2010Article
- Genome-wide functional analysis of human 5' untranslated region introns.Genome biology · 2010Article
- Article
- Evolution of alternative and constitutive regions of mammalian 5'UTRs.BMC genomics · 2009Article
- An approach to analyse the specific impact of rapamycin on mRNA-ribosome association.BMC medical genomics · 2008Article
- Impact of the Diversity in the 5' UTR on Translation Regulation.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of cellular proteins that play central roles in the regulation of cell growth and differentiation is frequently tightly controlled at the level of translation initiation. In this article, we provide evidence that the ETS domain transcription factor ELK-1 forms part of this class of genes. Its mRNA 5' UTR is composed of a complexed mosaic of elements, including uAUGs, uORFs and RNA structure, that interplay to modulate ribosomal access to the ELK-1 AUG start codon. Superimposed upon this is the generation of two different 5' UTRs via alternative splicing. The two spliced isoforms show altered cellular and tissue distributions and behave differently in polysomal recruitment assays in the presence of the drug rapamycin. We propose that repression is therefore the sum of a series of interplaying negative elements within the 5' UTRs, a situation which may reflect the need for tight translational control of ELK-1 in different tissues and under changing physiological conditions.
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