ReviewAlcohol (Fayetteville, N.Y.)2007
Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition.
Review in Alcohol (Fayetteville, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 129 citations in OpenAlex.
- The neurobiological markers of acute alcohol's subjective effects in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- Simultaneous edited MRS of GABA, glutathione, and ethanol.NMR in biomedicine · 2020Trial
- Central nervous system effects of alcohol at a pseudo-steady-state concentration using alcohol clamping in healthy volunteers.British journal of clinical pharmacology · 2009Trial
- Neurobiological Bases of Alcohol Consumption After Social Stress.Current topics in behavioral neurosciences · 2022Article
- Cellular interactions between social experience, alcohol sensitivity, and GABAergic inhibition in a crayfish neural circuit.Journal of neurophysiology · 2021Article
- Humulone Modulation of GABAFrontiers in neuroscience · 2020Article
- Mechanisms of GABAScientific reports · 2019Article
- Female-specific decreases in alcohol binge-like drinking resulting from GABAScientific reports · 2019Article
- Direction of action of presynaptic GABAJournal of neurophysiology · 2019Article
- Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model.Scientific reports · 2019Article
- High-intensity binge drinking is associated with alterations in spontaneous neural oscillations in young adults.Alcohol (Fayetteville, N.Y.) · 2018Article
- GABANeuropharmacology · 2018Review
- Ethanol Alters APP Processing and Aggravates Alzheimer-Associated Phenotypes.Molecular neurobiology · 2018Article
- The Cerebellar GABAHandbook of experimental pharmacology · 2018Article
- Missense Gamma-Aminobutyric Acid Receptor Polymorphisms Are Associated with Reaction Time, Motor Time, and Ethanol EffectsFrontiers in cellular neuroscience · 2018Article
- An Overview of the Mechanisms of Abnormal GABAergic Interneuronal Cortical Migration Associated with Prenatal Ethanol Exposure.Neurochemical research · 2017Review
- Intraperitoneal Administration of Ethanol as a Means of Euthanasia for Neonatal Mice (Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Sigma Receptors and Alcohol Use Disorders.Handbook of experimental pharmacology · 2017Review
- Neurochemical Markers in the Mammalian Brain: Structure, Roles in Synaptic Communication, and Pharmacological Relevance.Current medicinal chemistry · 2017Review
- Sigma Receptors and Substance Use Disorders.Advances in experimental medicine and biology · 2017Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Based on the similarity of ethanol intoxication to the behavioral effects of drugs known to target gamma-aminobutyric acid type A (GABAA) receptors (GABARs), it has been suspected for decades that ethanol facilitates the activity of GABA. Even so, it has been surprisingly difficult to identify molecular targets of ethanol. Research conducted over the past several years suggests that a subclass of GABARs (those containing delta subunits) responds in a relevant concentration range to ethanol. Although delta subunit-containing GABARs are not ubiquitously expressed at inhibitory synapses like their gamma subunit-containing, synaptic counterparts, they are found in many neurons in extrasynaptic locations. Here, they give rise to a tonic form of inhibition that can potently suppress neuronal excitability. Studies have shown that both recombinant and native delta subunit-containing GABARs (1) are modulated by behaviorally relevant (i.e., low millimolar) concentrations of ethanol, (2) directly bind ethanol over the same concentration range, (3) show altered function upon single amino substitutions linked to changes in behavioral responsiveness to ethanol, and (4) are a site of action of Ro15-4513, a competitive antagonist of ethanol binding and a drug which prevents many of the behavioral aspects of ethanol intoxication. Despite such comprehensive evidence, however, the field is not free from controversy. This review evaluates published data for and against a central role of delta subunit-containing GABARs in ethanol actions and suggests future directions that might help settle points of controversy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.