ReviewTrends in neurosciences2007
Differences in O2 availability resolve the apparent discrepancies in metabolic intrinsic optical signals in vivo and in vitro.
Review in Trends in neurosciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
- Contrasting Metabolic Insufficiency in Aging and Dementia.Aging and disease · 2021Review
- Relationship between oxygen consumption and neuronal activity in a defined neural circuit.BMC biology · 2020Article
- Rapid Postnatal Expansion of Neural Networks Occurs in an Environment of Altered Neurovascular and Neurometabolic Coupling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- High-resolution in vivo optical imaging of stroke injury and repair.Brain research · 2015Review
- A recording chamber for small volume slice electrophysiology.Journal of neurophysiology · 2015Article
- Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.Physiological reviews · 2015Review
- Metabolic responses differentiate between interictal, ictal and persistent epileptiform activity in intact, immature hippocampus in vitro.Neurobiology of disease · 2015Article
- Age-related metabolic fatigue during low glucose conditions in rat hippocampus.Neurobiology of aging · 2015Article
- Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Frontiers in optical imaging of cerebral blood flow and metabolism.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Review
- Cellular Links between Neuronal Activity and Energy Homeostasis.Frontiers in pharmacology · 2012Article
- Simultaneous monitoring of tissue PO2 and NADH fluorescence during synaptic stimulation and spreading depression reveals a transient dissociation between oxygen utilization and mitochondrial redox state in rat hippocampal slices.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Article
- Critical state of energy metabolism in brain slices: the principal role of oxygen delivery and energy substrates in shaping neuronal activity.Frontiers in neuroenergetics · 2011Article
- Lactate Effectively Covers Energy Demands during Neuronal Network Activity in Neonatal Hippocampal Slices.Frontiers in neuroenergetics · 2011Article
- Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2010Article
- Spatial Relationship between Flavoprotein Fluorescence and the Hemodynamic Response in the Primary Visual Cortex of Alert Macaque Monkeys.Frontiers in neuroenergetics · 2010Article
- Establishing a physiological environment for visualized in vitro brain slice recordings by increasing oxygen supply and modifying aCSF content.Journal of neuroscience methods · 2009Review
- Release of adenosine and ATP during ischemia and epilepsy.Current neuropharmacology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Monitoring changes in the fluorescence of metabolic chromophores, reduced nicotinamide adenine dinucleotide and flavin adenine dinucleotide, and the absorption of cytochromes, is useful to study neuronal activation and mitochondrial metabolism in the brain. However, these optical signals evoked by stimulation, seizures and spreading depression in intact brain differ from those observed in vitro. The responses in vivo consist of a persistent oxidized state during neuronal activity followed by mild reduction during recovery. In vitro, however, brief oxidation is followed by prolonged and heightened reduction, even during persistent neuronal activation. In normally perfused, oxygenated and activated brain tissue in vivo, partial pressure of oxygen (P(O2)) levels often undergo a brief 'dip' that is always followed by an overshoot above baseline, due to increased blood flow (neuronal-vascular coupling). By contrast, in the absence of blood circulation, tissue P(O2)in vitro decreases more markedly and recovers slowly to baseline without overshooting. Although oxygen is abundant in vivo, it is diffusion-limited in vitro. The disparities in mitochondrial and tissue oxygen availability account for the different redox responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.