ArticleWorld journal of gastroenterology2007
Frequency of primary iron overload and HFE gene mutations (C282Y, H63D and S65C) in chronic liver disease patients in north India.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- HFE genetic variability and risk of alcoholic liver disease: A meta-analysis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Pooled it
- Significance of Hereditary Hemochromatosis Gene (HFE) Mutations in Chronic Hepatitis C and Hepatocellular Carcinoma Patients in Egypt: A Pilot Study.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Primary haemochromatosis resulting in dilated cardiomyopathy arising out of mutation in HJV gene in Indian patients: a rare scenario.BMJ case reports · 2020Article
- Non-HFE iron overload as a surrogate marker of disease severity in patients of liver cirrhosis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2016Article
- The Riddle of Nonalcoholic Fatty Liver Disease: Progression From Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis.Journal of clinical and experimental hepatology · 2015Review
- Body iron stores in middle-aged North Indian patients with type 2 diabetes and obesity.Journal of mid-life health · 2014Article
- Article
- H63D mutation in HFE gene is common in Indians and is associated with the European haplotype.Journal of genetics · 2012Article
- Unique frequencies of HFE gene variants in Roma/Gypsies.Journal of applied genetics · 2012Article
- Iron metabolism in Nonalcoholic Fatty Liver Disease.Current gastroenterology reports · 2012Review
- Iron overload and HFE mutations: are they relevant in cryptogenic cirrhosis?Hepatitis monthly · 2012Article
- Primary iron overload and HFE gene mutations in North Indian adults.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2012Article
- Frequency of Two Common HFE Gene Mutations (C282Y and H63D) in a Group of Iranian Patients With Cryptogenic Cirrhosis.Hepatitis monthly · 2011Article
- Lack of association of primary iron overload and common HFE gene mutations with liver cirrhosis in adult Indian population.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2011Article
- Obscure pathogenesis of primary iron overload in Indians warrants more focused research.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2011Article
- Hemochromatosis in India: First Report of Whole Exome Sequencing With Review of the Literature.Journal of clinical and experimental hepatologyArticle
- Article
- Etiological Spectrum of Cirrhosis in India: A Systematic Review and Meta-analysis.Journal of clinical and experimental hepatologyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo identify the frequency of iron overload and study the three mutations in the HFE gene (C282Y, H63D, and S65C) in patients with chronic liver disorders (CLD) and controls.
methodsTo identify patients with iron overload (transferrin saturation > 45% in females and > 50% in males and serum ferritin > 1000 ng/mL) we evaluated 236 patients with CLD, including 59 with non-alcoholic steatohepatitis (NASH), 22 with alcoholic liver disease (ALD), 19 of cirrhosis due to viruses (HBV, HCV), and 136 with cryptogenic cirrhosis. Mutations of the HFE gene were analyzed by PCR-RE. hundred controls were screened for iron status and the mutations.
resultsSeventeen patients with CLD showed evidence of iron overload. Fifteen cases of iron overload had cryptogenic cirrhosis and two had ALD. None of the controls showed iron overload. We did not find any individual with 282Y or 65C either in the cases or in the controls. The prevalence of H63D heterozygosity was 12% in normal individuals, 14.8% in 236 patients (16.9% in NASH, 13.6% in ALD, 26.3% in viral and 12.5% in cryptogenic cirrhosis) and the overall prevalence was 13.98%. Only two of the 17 patients with primary iron overload were heterozygous for H63D. One patient with NASH and one normal individual who were homozygous for H63D showed no iron overload.
conclusionPrimary iron overload in Indians is non-HFE type, which is different from that in Europeans and further molecular studies are required to determine the defect in various iron regulatory genes.
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