ArticleWorld journal of gastroenterology2007
Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran).
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Burden of gastric cancer attributable to Helicobacter pylori in 27 countries from seven geographic regions in 2022.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Pooled it
- Pooled it
- Epidemiology of Helicobacter pylori infection among the healthy population in Iran and countries of the Eastern Mediterranean Region: a systematic review of prevalence and risk factors.World journal of gastroenterology · 2014Pooled it
- Genetic susceptibility and gene-environment interactions in gastric cancer among ethnic populations of Northeast India.Scientific reports · 2026Article
- A Population-Based Cross-sectional Study on the Prevalence and Associated Risk Factors ofMiddle East journal of digestive diseases · 2022Article
- Helicobacter Pylori Infection in Children with Type 1 Diabetes Mellitus: A Case-Control Study.Journal of research in health sciences · 2016Article
- Estimation of Cancer Burden Attributable to Infection in Asia.Journal of epidemiology · 2015Review
- Evaluation of Helicobacter pylori vacA and cagA Genotypes and Correlation With Clinical Outcome in Patients With Dyspepsia in Hamadan Province, Iran.Iranian Red Crescent medical journal · 2014Article
- Seroprevalence of anti-Helicobacter pylori and anti-cytotoxin-associated gene A antibodies among healthy individuals in center of Iran.Iranian journal of basic medical sciences · 2014Article
- Association between Helicobacter pylori, cagA, and vacA Status and Clinical Presentation in Iranian Children.Iranian journal of pediatrics · 2013Article
- Higher serum levels of rheumatoid factor and anti-nuclear antibodies in helicobacter pylori-infected peptic ulcer patients.Oman medical journal · 2013Article
- Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagA.Iranian journal of microbiology · 2013Article
- Diversity of Helicobacter Pylori cagA and vacA Genes and Its Relationship with Clinical Outcomes in Azerbaijan, Iran.Advanced pharmaceutical bulletin · 2013Article
- Helicobacter pylori Infection in the general population: A Middle Eastern perspective.Caspian journal of internal medicine · 2013Review
- Frequency of Helicobacter pylori and cytotoxine associated gene A antibodies in patients with cardiac syndrome X.Journal of cardiovascular disease research · 2012Article
- Helicobacter pylori infection might be responsible for the interconnection between type 1 diabetes and autoimmune thyroiditis.Diabetology & metabolic syndrome · 2011Article
- cagA and vacA status and influence of Helicobacter pylori infection on serum oxidative DNA damage in Iranian patients with peptic ulcer disease.Irish journal of medical science · 2011Article
- Review of Helicobacter pylori infection and chronic renal failure.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2011Review
- Effect of Helicobacter pylori infection on pregnancy rates and early pregnancy loss after intracytoplasmic sperm injection.International journal of women's health · 2011Article
- Analysis of Helicobacter pylori genotypes in Afghani and Iranian isolates.Polish journal of microbiology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the serologic IgG response to H pylori and CagA across age groups and in healthy children and adults.
methodsTotally, 386 children aged 1-15 years and 200 adults aged 20-60 years, were enrolled to study. The serum samples of participant were tested for presence of anti-H pylori and anti-CagA IgG by using ELISA method.
resultsThe seroprevalence of H pylori in adults was significantly higher than that observed in children (67.5% vs 46.6%; P < 0.000003). In children, the seropositivity rate in males (51.9%) was significantly (P < 0.05) higher than that observed in females (41.7%). The prevalence of serum anti-CagA antibody was 72.8% and 67.4% in infected children and adults, respectively. The mean titer of serum anti-CagA antibodies was significantly higher among children in comparison to adults (64.1 Uarb/mL vs 30.7; P < 0.03). In infected children and adults the prevalence of serum anti-CagA antibody was higher in males compared to females (78.4% vs 66.3%; P = 0.07 and 75.6% vs 54.71%; P < 0.04, respectively). The age-specific prevalence of anti-H pylori and anti-CagA antibody (in infected subjects) was 37.6% and 59.57% at age 1-5 years, 46.9% and 75% at age 6-10 years, 54.9% and 79.45% at age 11-15, 59.01% and 83.33% at age 20-30 years, 66.6% and 60.52% at age 31-40 years, 73.46% and 63.88% at age 41-50 years and 75.75% and 60% at age 51-60 years with mean titer of anti-CagA antibody of 75.94, 63.32, 57.11, 52.06, 23.62, 21.52 and 21.80 Uarb/mL, respectively. There was significant difference between mean serum anti-CagA antibody in age subgroups (P < 0.001).
conclusionThese results showed that anti-H pylori and anti-CagA antibodies were common in the children and adults. The H pylori-specific antibodies influenced by age and sex of subjects. Moreover, it seems that males are more susceptible to infection with CagA(+) strains compared to females. The seroprevalence of anti-CagA antibody was increased with age, up to 30 years and then decreased. It was also found that the magnitude of the IgG response to CagA decreased with advanced age.
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