Evidence map›Paper›PMID 17589600›Full record

ArticleEnvironmental health perspectives2007

Reduction in urinary arsenic levels in response to arsenic mitigation efforts in Araihazar, Bangladesh.

Yu Chen, Alexander van Geen, Joseph H Graziano, Alexander Pfaff, Malgosia Madajewicz, Faruque Parvez, A Z M Iftekhar Hussain, Vesna Slavkovich, Tariqul Islam, Habibul Ahsan

Abstract read
In one paragraph

Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  7. Folic acid supplementation lowers blood arsenic.The American journal of clinical nutrition · 2007
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yu ChenDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
Alexander van Geen
Joseph H Graziano
Alexander Pfaff
Malgosia Madajewicz
Faruque Parvez
A Z M Iftekhar Hussain
Vesna Slavkovich
Tariqul Islam
Habibul Ahsan

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
Training CoreP42ES010349 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NAVAS-ACIEN, ANA · 2000 to 2020
$53.6M
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX · 1985 to 2020
$26.1M
Chemoprevention of arsenic-induced skin cancerR01CA107431 · NCI · UNIVERSITY OF CHICAGO · PI AHSAN, HABIBUL · 2005 to 2014
$17.3M
Genetic Susceptibility to Arsenic-induced Skin CancerR01CA102484 · NCI · UNIVERSITY OF CHICAGO · PI AHSAN, HABIBUL · 2004 to 2008
$2.0M
NCI NIH HHS CA016087NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA102484NCI NIH HHS R01CA102484NCI NIH HHS R01 CA107431NCI NIH HHS R01CA107431NIEHS NIH HHS ES000260NIEHS NIH HHS P30 ES000260NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30ES09089NIEHS NIH HHS P42 ES010349NIEHS NIH HHS P42ES10349
6 · The paper itself

Abstract

backgroundThere is a need to identify and evaluate an effective mitigation program for arsenic exposure from drinking water in Bangladesh.

objectiveWe evaluated the effectiveness of a multifaceted mitigation program to reduce As exposure among 11,746 individuals in a prospective cohort study initiated in 2000 in Araihazar, Bangladesh, by interviewing participants and measuring changes in urinary As levels.

methodsThe interventions included a) person-to-person reporting of well test results and health education; b) well labeling and village-level health education; and c) installations of 50 deep, low-As community wells in villages with the highest As exposure.

resultsTwo years after these interventions, 58% of the 6,512 participants with unsafe wells (As >/=50 microg) at baseline had responded by switching to other wells. Well labeling and village-level health education was positively related to switching to safe wells (As < 50 mug/L) among participants with unsafe wells [rate ratio (RR) = 1.84; 95% confidence interval (CI), 1.60-2.11] and inversely related to any well switching among those with safe wells (RR = 0.80; 95% CI, 0.66-0.98). The urinary As level in participants who switched to a well identified as safe (< 50 microg As/L) dropped from an average of 375 microg As/g creatinine to 200 microg As/g creatinine, a 46% reduction toward the average urinary As content of 136 microg As/g creatinine for participants that used safe wells throughout. Urinary As reduction was positively related to educational attainment, body mass index, never-smoking, absence of skin lesions, and time since switching (p for trend < 0.05).

conclusionsOur study shows that testing of wells and informing households of the consequences of As exposure, combined with installation of deep community wells where most needed, can effectively address the continuing public health emergency from arsenic in drinking water in Bangladesh.

Indexed as

Environmental ExposureAdolescentAdultAgedArsenicArsenic PoisoningBangladeshFemaleHealth EducationHumansInterviews as TopicMaleMiddle AgedWater Pollutants, ChemicalWater SupplyArsenicWater Pollutants, Chemical

Identifiers

PMID17589600
PMCPMC1892113

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.