ArticleEnvironmental health perspectives2007
PBTK modeling demonstrates contribution of dermal and inhalation exposure components to end-exhaled breath concentrations of naphthalene.
Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- [Progress in the metabolic and biotransformation of polycyclic aromatic hydrocarbons and their derivatives in humans].Se pu = Chinese journal of chromatography · 2025Review
- Estimation of Dermal Exposure to Volatile Organic Compounds (VOCs) from Feminine Hygiene Products: Integrating Measurement Data and Physiologically Based Toxicokinetic (PBTK) Model.Environmental health perspectives · 2025Article
- Exploring Route-Specific Pharmacokinetics of PFAS in Mice by CouplingEnvironmental health perspectives · 2023Article
- Health Effects of Naphthalene Exposure: A Systematic Evidence Map and Analysis of Potential Considerations for Dose-Response Evaluation.Environmental health perspectives · 2021Article
- A Physiologically Based Pharmacokinetic Model for Naphthalene With Inhalation and Skin Routes of Exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- A review of PAH exposure from the combustion of biomass fuel and their less surveyed effect on the blood parameters.Environmental science and pollution research international · 2015Review
- The toxic effects of cigarette additives. Philip Morris' project mix reconsidered: an analysis of documents released through litigation.PLoS medicine · 2011Article
- The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2011Article
- Exposure to naphthalene induces naphthyl-keratin adducts in human epidermis in vitro and in vivo.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2010Article
- Mathematical description of the uptake of hydrocarbons in jet fuel into the stratum corneum of human volunteers.Toxicology letters · 2008Article
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6 authors.
Funding
Abstract
backgroundDermal and inhalation exposure to jet propulsion fuel 8 (JP-8) have been measured in a few occupational exposure studies. However, a quantitative understanding of the relationship between external exposures and end-exhaled air concentrations has not been described for occupational and environmental exposure scenarios.
objectiveOur goal was to construct a physiologically based toxicokinetic (PBTK) model that quantitatively describes the relative contribution of dermal and inhalation exposures to the end-exhaled air concentrations of naphthalene among U.S. Air Force personnel.
methodsThe PBTK model comprised five compartments representing the stratum corneum, viable epidermis, blood, fat, and other tissues. The parameters were optimized using exclusively human exposure and biological monitoring data.
resultsThe optimized values of parameters for naphthalene were a) permeability coefficient for the stratum corneum 6.8 x 10(-5) cm/hr, b) permeability coefficient for the viable epidermis 3.0 x 10(-3) cm/hr, c) fat:blood partition coefficient 25.6, and d) other tissue:blood partition coefficient 5.2. The skin permeability coefficient was comparable to the values estimated from in vitro studies. Based on simulations of workers' exposures to JP-8 during aircraft fuel-cell maintenance operations, the median relative contribution of dermal exposure to the end-exhaled breath concentration of naphthalene was 4% (10th percentile 1% and 90th percentile 11%).
conclusionsPBTK modeling allowed contributions of the end-exhaled air concentration of naphthalene to be partitioned between dermal and inhalation routes of exposure. Further study of inter- and intraindividual variations in exposure assessment is required to better characterize the toxicokinetic behavior of JP-8 components after occupational and/or environmental exposures.
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