ArticleThe Journal of biological chemistry2007
The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding.
Article in The Journal of biological chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 108 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
108 citing papers in PubMed, 1 synthesis or guideline pooled it, 256 citations in OpenAlex.
- Association of maternal AGTR1 polymorphisms and preeclampsia: a systematic review and meta-analysis.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2012Pooled it
- The association of blood angioregulatory microRNA levels with circulating endothelial cells and angiogenic proteins in patients receiving dacarbazine and interferon.Journal of translational medicine · 2012Trial
- The Protective Effects of Neurotrophins and MicroRNA in Diabetic Retinopathy, Nephropathy and Heart Failure via Regulating Endothelial Function.Biomolecules · 2022Review
- Association amongst human A1166C polymorphism of the angiotensin II type 1 receptor gene with coronary artery disease in the Iraqi population.Journal of diabetes and metabolic disorders · 2022Article
- Allele С (rs5186) of at1r is associated with the severity of COVID-19 in the Ukrainian population.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2022Observational
- Review
- SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes.Frontiers in genetics · 2021Review
- Angiotensin II type 1 receptor gene polymorphism and serum angiotensin-converting enzyme level in Egyptian children with systemic lupus erythematosus.Clinical rheumatology · 2018Article
- MiR-1-3p that correlates with left ventricular function of HCM can serve as a potential target and differentiate HCM from DCM.Journal of translational medicine · 2018Article
- 3'-UTR Polymorphisms of MTHFR and TS Associated with Osteoporotic Vertebral Compression Fracture Susceptibility in Postmenopausal Women.International journal of molecular sciences · 2018Article
- Screening key genes for abdominal aortic aneurysm based on gene expression omnibus dataset.BMC cardiovascular disorders · 2018Article
- Renin-angiotensin system gene polymorphisms as potential modifiers of hypertrophic and dilated cardiomyopathy phenotypes.Molecular and cellular biochemistry · 2017Article
- Diabetic Cardiomyopathy: An Immunometabolic Perspective.Frontiers in endocrinology · 2017Review
- Identification of a New Single-nucleotide Polymorphism within the Apolipoprotein A5 Gene, Which is Associated with Metabolic Syndrome.Advanced biomedical research · 2017Article
- Racial differences in microRNA and gene expression in hypertensive women.Scientific reports · 2016Article
- MicroRNAs and Endothelial (Dys) Function.Journal of cellular physiology · 2016Review
- Antagonist Targeting microRNA-155 Protects against Lithium-Pilocarpine-Induced Status Epilepticus in C57BL/6 Mice by Activating Brain-Derived Neurotrophic Factor.Frontiers in pharmacology · 2016Article
- Mechanisms and therapeutic potential of microRNAs in hypertension.Drug discovery today · 2015Review
- Circulating and renal vein levels of microRNAs in patients with renal artery stenosis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2015Article
- A solute carrier family 22 member 3 variant rs3088442 G→A associated with coronary heart disease inhibits lipopolysaccharide-induced inflammatory response.The Journal of biological chemistry · 2015Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2013-02-08Ethical Violations by Author · Falsification/Fabrication of Image · Investigation by ORI ·
- Commented on by
- Commented on by
- Retracted
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
The adverse effects of angiotensin II (Ang II) are primarily mediated through the Ang II type 1 receptor (AT1R). A silent polymorphism (+1166 A/C) in the human AT1R gene has been associated with cardiovascular disease, possibly as a result of enhanced AT(1)R activity. Because this polymorphism occurs in the 3'-untranslated region of the human AT1R gene, the biological importance of this mutation has always been questionable. Computer alignment demonstrated that the +1166 A/C polymorphism occurred in a cis-regulatory site, which is recognized by a specific microRNA (miRNA), miR-155. miRNAs are noncoding RNAs that silence gene expression by base-pairing with complementary sequences in the 3'-untranslated region of target RNAs. When the +1166 C-allele is present, base-pairing complementarity is interrupted, and the ability of miR-155 to interact with the cis-regulatory site is decreased. As a result, miR-155 no longer attenuates translation as efficiently as demonstrated by luciferase reporter and Ang II radioreceptor binding assays. In situ hybridization experiments demonstrated that mature miR-155 is abundantly expressed in the same cell types as the AT1R (e.g. endothelial and vascular smooth muscle). Finally, when human primary vascular smooth muscle cells were transfected with an antisense miR-155 inhibitor, endogenous human AT1R expression and Ang II-induced ERK1/2 activation were significantly increased. Taken together, our study demonstrates that the AT1R and miR-155 are co-expressed and that miR-155 translationally represses the expression of AT1R in vivo. Therefore, our study provides the first feasible biochemical mechanism by which the +1166 A/C polymorphism can lead to increased AT1R densities and possibly cardiovascular disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.