Trial reportPsychopharmacology2007
Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity.
Trial report in Psychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the pharmacological modulation of autobiographical memory specificity.Frontiers in psychology · 2022Pooled it
- Noradrenergic mechanisms of arousal's bidirectional effects on episodic memory.Neurobiology of learning and memory · 2017Trial
- Noradrenergic enhancement of amygdala responses to fear.Social cognitive and affective neuroscience · 2009Trial
- Emotional salience modulates the forward-flow of memory.Royal Society open science · 2024Article
- The limited reach of surprise: Evidence against effects of surprise on memory for preceding elements of an event.Psychonomic bulletin & review · 2022Article
- Pharmacological treatment of PTSD - established and new approaches.Neuropharmacology · 2012Review
- Stimulus intensity-dependent modulations of hippocampal long-term potentiation by basolateral amygdala priming.Frontiers in cellular neuroscience · 2012Article
- Time-dependent effects of cortisol on selective attention and emotional interference: a functional MRI study.Frontiers in integrative neuroscience · 2012Article
- Opposing influences of affective state valence on visual cortical encoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The limits of arousal's memory-impairing effects on nearby information.The American journal of psychology · 2009Article
- Modeling a negative response bias in the human amygdala by noradrenergic-glucocorticoid interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Noradrenergic-glucocorticoid mechanisms in emotion-induced amnesia: from adaptation to disease.Psychopharmacology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
rationalePrivileged episodic encoding of an aversive event often comes at a cost of neutral events flanking the aversive event, resulting in decreased episodic memory for these neutral events. This peri-emotional amnesia is amygdala-dependent and varies as a function of norepinephrine activity. However, less is known about the amnesiogenic potential of cortisol.
objectiveWe used a strategy of pharmacologically potentiating cortisol and norepinephrine activity to probe the putative neurochemical substrates of peri-emotional amnesia. MATERIALS AND
methodsFifty-four healthy individuals participated in a randomized double-blind placebo-controlled study. Within the experimental context of an established peri-emotional amnesia paradigm, we tested the amnesiogenic potential of hydrocortisone (30 mg p.o.) in the presence or absence of the norepinephrine-reuptake inhibitor reboxetine (4 mg p.o.).
resultsUnder dual challenge conditions, we observed a linear dose-response relationship in the magnitude and duration of emotion-induced retrograde amnesia.
conclusionsOur results are consistent with a phenotypic expression of retrograde amnesia varying as a function of norepinephrine and cortisol coactivation during episodic encoding of aversive events. Our study demonstrates that the adverse cognitive and behavioral sequelae of aversive emotion can be experimentally modeled by a pharmacological manipulation of its putative neurochemical substrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.