ArticleAntonie van Leeuwenhoek
Comparative genomics of Streptomyces avermitilis, Streptomyces cattleya, Streptomyces maritimus and Kitasatospora aureofaciens using a Streptomyces coelicolor microarray system.
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12 citing papers in PubMed, 38 citations in OpenAlex.
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- Localization of Pyranose 2-Oxidase fromInternational journal of molecular sciences · 2023Article
- A DasA family sugar binding protein Ste2 links nutrient and oxidative stress to exopolysaccharides production in Streptomyces sp. 139.BMC microbiology · 2022Article
- Antibiotic resistance in plant growth promoting bacteria: A comprehensive review and future perspectives to mitigate potential gene invasion risks.Frontiers in microbiology · 2022Review
- High-Throughput Transcriptional Characterization of Regulatory Sequences from Bacterial Biosynthetic Gene Clusters.ACS synthetic biology · 2021Article
- Reconstruction of Secondary Metabolic Pathway to Synthesize Novel Metabolite inFrontiers in bioengineering and biotechnology · 2021Article
- LacI-Family Transcriptional Regulator DagR Acts as a Repressor of the Agarolytic Pathway Genes inFrontiers in microbiology · 2021Article
- Article
- Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomics.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2013Review
- Species' identification and microarray-based comparative genome analysis of Streptomyces species isolated from potato scab lesions in Norway.Molecular plant pathology · 2012Article
- Microarray-based comparison of genetic differences between strains of Streptomyces turgidiscabies with focus on the pathogenicity island.Molecular plant pathology · 2010Article
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2 authors at 1 institution in 1 country.
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Abstract
DNA/DNA microarray hybridization was used to compare the genome content of Streptomyces avermitilis, Streptomyces cattleya, Streptomyces maritimus and Kitasatospora aureofaciens with that of Streptomyces coelicolor A3(2). The array data showed an about 93% agreement with the genome sequence data available for S. avermitilis and also showed a number of trends in the genome structure for Streptomyces and closely related Kitasatospora. A core central region was well conserved, which might be predicted from previous research and this was linked to a low degree of gene conservation in the terminal regions of the linear chromosome across all four species. Between these regions there are two areas of intermediate gene conservation by microarray analysis where gene synteny is still detectable in S. avermitilis. Nonetheless, a range of conserved genes could be identified within the terminal regions. Variation in the genes involved in differentiation, transcription, DNA replication, etc. provides interesting insights into which genes in these categories are generally conserved and which are not. The results also provide target priorities for possible gene knockouts in a group of bacteria with a very large numbers of genes with unknown functions compared to most bacterial species.
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