ReviewCells, tissues, organs2007
Complexity in interpretation of embryonic epithelial-mesenchymal transition in response to transforming growth factor-beta signaling.
Review in Cells, tissues, organs, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Anticancer Activity ofNutrients · 2025Article
- Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-β signaling.Scientific reports · 2021Article
- MicroRNA-708 targeting ZNF549 regulates colon adenocarcinoma development through PI3K/AKt pathway.Scientific reports · 2020Article
- TGF-β Signaling and the Epithelial-Mesenchymal Transition during Palatal Fusion.International journal of molecular sciences · 2018Review
- Effect of epithelial growth factor on matrix metalloproteinase-2 and E-cadherin/β-catenin expression in anOncology letters · 2017Article
- An early-screening biomarker of endometrial carcinoma: NGAL is associated with epithelio-mesenchymal transition.Oncotarget · 2016Article
- Population Heterogeneity in the Epithelial to Mesenchymal Transition Is Controlled by NFAT and Phosphorylated Sp1.PLoS computational biology · 2016Article
- The microRNA networks of TGFβ signaling in cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- The role of microRNAs in prostate cancer progression.Translational andrology and urology · 2013Review
- Epithelial-mesenchymal transition in oral squamous cell carcinoma.ISRN oncology · 2012Article
- The expression of TGF-β3 for epithelial-mesenchyme transdifferentiated MEE in palatogenesis.Journal of molecular histology · 2010Article
- Co-expression of FBN1 with mesenchyme-specific genes in mouse cell lines: implications for phenotypic variability in Marfan syndrome.European journal of human genetics : EJHG · 2010Article
- Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21Cip1 or Rb status.BMC cancer · 2008Article
- Identification of Smad-dependent and -independent signaling with transforming growth factor-β type 1/2 receptor inhibition in palatogenesis.Journal of oral biology and craniofacial researchArticle
- Hierarchical approaches for systems modeling in cardiac development.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Epithelial-mesenchymal transition (EMT) is a highly conserved and fundamental process that governs morphogenesis in development and may also contribute to cancer metastasis. Transforming growth factor (TGF-beta) is a potent inducer of EMT in various developmental and tumor systems. The analysis of TGF-beta signal transduction pathways is now considered a critically important area of biology, since many defects occur in these pathways in embryonic development. The complexity of TGF-beta signal transduction networks is overwhelming due to the large numbers of interacting constituents, complicated feedforward, feedback and crosstalk circuitry mechanisms that they involve in addition to the cellular kinetics and enzymatics that contribute to cell signaling. As a result of this complexity, apparently simple but highly important questions remain unanswered, that is, how do epithelial cells respond to such TGF-beta signals? System biology and cellular kinetics play a crucial role in cellular function; omissions of such a critical contributor may lead to inaccurate understanding of embryonic EMT. In this review, we identify and explain why certain conditions need to be considered for a true representation of TGF-beta signaling in vivo to better understand the controlled, yet delicate mechanism of embryonic EMT.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.