ReviewCurrent opinion in structural biology2007
Structural genomics: keeping up with expanding knowledge of the protein universe.
Review in Current opinion in structural biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Divergence and conservation of defensins and lipid transfer proteins (LTPs) from sugarcane wild species and modern cultivar genomes.Functional & integrative genomics · 2022Article
- ResiRole: residue-level functional site predictions to gauge the accuracies of protein structure prediction techniques.Bioinformatics (Oxford, England) · 2021Article
- In Situ Proteolysis Condition-Induced Crystallization of the XcpVWX Complex in Different Lattices.International journal of molecular sciences · 2020Article
- The impact of structural genomics: the first quindecennial.Journal of structural and functional genomics · 2016Review
- X-ray crystallography over the past decade for novel drug discovery - where are we heading next?Expert opinion on drug discovery · 2015Review
- Assessing the accuracy of template-based structure prediction metaservers by comparison with structural genomics structures.Journal of structural and functional genomics · 2012Article
- 'Seeding' with protease to optimize protein crystallization conditions in in situ proteolysis.Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
- Structural characterization of Helicobacter pylori dethiobiotin synthetase reveals differences between family members.The FEBS journal · 2012Article
- Catalytic residues in hydrolases: analysis of methods designed for ligand-binding site prediction.Journal of computer-aided molecular design · 2011Article
- Extending CATH: increasing coverage of the protein structure universe and linking structure with function.Nucleic acids research · 2011Article
- A conserved helical capping hydrogen bond in PAS domains controls signaling kinetics in the superfamily prototype photoactive yellow protein.Journal of the American Chemical Society · 2010Article
- Comprehensive structural and functional characterization of the human kinome by protein structure modeling and ligand virtual screening.Journal of chemical information and modeling · 2010Article
- Mass spectrometry guided in situ proteolysis to obtain crystals for X-ray structure determination.Journal of the American Society for Mass Spectrometry · 2010Article
- From protein sequences to 3D-structures and beyond: the example of the UniProt knowledgebase.Cellular and molecular life sciences : CMLS · 2010Review
- Benefits of structural genomics for drug discovery research.Infectious disorders drug targets · 2009Review
- Protein function annotation by homology-based inference.Genome biology · 2009Review
- Article
- Evolutionary relationship between defensins in the Poaceae family strengthened by the characterization of new sugarcane defensins.Plant molecular biology · 2008Article
- FireDock: a web server for fast interaction refinement in molecular docking.Nucleic acids research · 2008Article
- Iron-sulfur protein folds, iron-sulfur chemistry, and evolution.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Structural characterization of the protein universe is the main mission of Structural Genomics (SG) programs. However, progress in gene sequencing technology, set in motion in the 1990s, has resulted in rapid expansion of protein sequence space--a twelvefold increase in the past seven years. For the SG field, this creates new challenges and necessitates a re-assessment of its strategies. Nevertheless, despite the growth of sequence space, at present nearly half of the content of the Swiss-Prot database and over 40% of Pfam protein families can be structurally modeled based on structures determined so far, with SG projects making an increasingly significant contribution. The SG contribution of new Pfam structures nearly doubled from 27.2% in 2003 to 51.6% in 2006.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.