ReviewJournal of mammary gland biology and neoplasia2007
Metastasis suppressors and their roles in breast carcinoma.
Review in Journal of mammary gland biology and neoplasia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer.Exploration of targeted anti-tumor therapy · 2023Review
- Assessment the Effect of Human Umbilical Cord Wharton's Jelly Stem Cells on the Expression of Homing Genes; CXCR4 and VLA-4 in Cell Line of Breast Cancer.International journal of hematology-oncology and stem cell research · 2022Article
- Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets.Signal transduction and targeted therapy · 2021Review
- Anti-metastatic effect of ranolazine in an in vivo rat model of prostate cancer, and expression of voltage-gated sodium channel protein in human prostate.Prostate cancer and prostatic diseases · 2019Article
- Breast cancer metastasis suppressor-1 promoter methylation in cell-free DNA provides prognostic information in non-small cell lung cancer.British journal of cancer · 2014Article
- Breast cancer metastasis suppressor-1 promoter methylation in primary breast tumors and corresponding circulating tumor cells.Molecular cancer research : MCR · 2013Article
- LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker.Nature medicine · 2012Article
- Identification of metastasis-associated breast cancer genes using a high-resolution whole genome profiling approach.Journal of cancer research and clinical oncology · 2011Article
- Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α.Journal of the National Cancer Institute · 2011Article
- Metastasis suppressor genes at the interface between the environment and tumor cell growth.International review of cell and molecular biology · 2011Review
- Antiproliferative effect of D-glucuronyl C5-epimerase in human breast cancer cells.Cancer cell international · 2010Article
- The KISS1 metastasis suppressor: a good night kiss for disseminated cancer cells.European journal of cancer (Oxford, England : 1990) · 2010Review
- Expression of the Breast Cancer Metastasis Suppressor 1 (BRMS1) maintains in vitro chemosensitivity of breast cancer cells.Cancer letters · 2009Article
- Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis.Cancer research · 2009Article
- Functional expression of voltage-gated sodium channels Nav1.5 in human breast cancer cell line MDA-MB-231.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2009Article
- Multiple forms of BRMS1 are differentially expressed in the MCF10 isogenic breast cancer progression model.Clinical & experimental metastasis · 2009Article
- Metastasis suppressors and the tumor microenvironment.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2008Article
- Breast cancer metastasis suppressor-1 differentially modulates growth factor signaling.The Journal of biological chemistry · 2008Article
- BRMS1 suppresses breast cancer experimental metastasis to multiple organs by inhibiting several steps of the metastatic process.The American journal of pathology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Metastasis remains the most deadly aspect of cancer and still evades direct treatment. Clinically and experimentally, primary tumor development and metastasis are distinct processes-locally growing tumors can progress without the development of metastases. The discovery of endogenous molecules that exclusively inhibit metastasis suggests that metastasis is an amenable therapeutic target. By definition, metastasis suppressors inhibit metastasis without inhibiting tumorigenicity and are thus distinct from tumor suppressors. As the biology underlying functional mechanisms of metastasis suppressors becomes clearer, it is evident that metastasis suppressors could be harnessed as direct drug targets, prognostic markers, and to understand the fundamental biology of the metastatic process. Metastasis suppressors vary widely in their cellular localization: they are found in every cellular compartment and some are secreted. In general, metastasis suppressors appear to regulate selectively how cells respond to exogenous signals, by affecting signaling cascades which regulate downstream gene expression. This review briefly summarizes current functional and biochemical data on metastasis suppressors implicated in breast cancer. We also present a schematic integrating known mechanisms for these metastasis suppressors highlighting potential targets for therapeutic intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.