ArticleEukaryotic cell2007
Conservation of PEX19-binding motifs required for protein targeting to mammalian peroxisomal and trypanosome glycosomal membranes.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Colab-PEX19BS: An Automated Google Colab Notebook-Based Tool for Detecting PEX19-Binding Sites.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Mapping Trypanosoma Protein Interactome by Proximity-Dependent Biotinylation.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Glycosomal ABC transporter 3 (GAT3) deletion enhances the oxidative stress responses and reduces the infectivity of Trypanosoma cruzi.PLoS neglected tropical diseases · 2025Article
- You can go your own way: The targeting signals of trypanosomatid parasites.PLoS pathogens · 2025Article
- Adaptive evolution of stress response genes in parasites aligns with host niche diversity.BMC biology · 2025Article
- Molecular basis of the glycosomal targeting of PEX11 and its mislocalization to mitochondrion in trypanosomes.Frontiers in cell and developmental biology · 2023Article
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- The early-acting glycosome biogenic protein Pex3 is essential for trypanosome viability.Life science alliance · 2019Article
- Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.Nature communications · 2017Article
- Evolutionary loss of peroxisomes--not limited to parasites.Biology direct · 2015Article
- Using fluorescent proteins to monitor glycosome dynamics in the African trypanosome.Journal of visualized experiments : JoVE · 2014Article
- Glycolysis in the african trypanosome: targeting enzymes and their subcellular compartments for therapeutic development.Molecular biology international · 2011Article
- Leishmania infantum chagasi: a genome-based approach to identification of excreted/secreted proteins.Experimental parasitology · 2010Article
- The Arabidopsis peroxisomal ABC transporter, comatose, complements the Saccharomyces cerevisiae pxa1 pxa2Delta mutant for metabolism of long-chain fatty acids and exhibits fatty acyl-CoA-stimulated ATPase activity.The Journal of biological chemistry · 2010Article
- Diverse effects on mitochondrial and nuclear functions elicited by drugs and genetic knockdowns in bloodstream stage Trypanosoma brucei.PLoS neglected tropical diseases · 2010Article
- Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.The EMBO journal · 2009Article
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Authors and funding
7 authors.
Funding
Abstract
Glycosomes are divergent peroxisomes found in trypanosomatid protozoa, including those that cause severe human diseases throughout much of the world. While peroxisomes are dispensable for both yeast (Saccharomyces cerevisiae and others) and mammalian cells in vitro, glycosomes are essential for trypanosomes and hence are viewed as a potential drug target. The import of proteins into the matrix of peroxisomes utilizes multiple peroxisomal membrane proteins which require the peroxin PEX19 for insertion into the peroxisomal membrane. In this report, we show that the specificity of peroxisomal membrane protein binding for Trypanosoma brucei PEX19 is very similar to those previously identified for human and yeast PEX19. Our studies show that trafficking is conserved across these distant phyla and that both a PEX19 binding site and a transmembrane domain are required for the insertion of two test proteins into the glycosomal membrane. However, in contrast to T. brucei PEX10 and PEX12, T. brucei PEX14 does not traffic to human peroxisomes, indicating that it is not recognized by the human PEX14 import mechanism.
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