Evidence map›Paper›PMID 17586623›Full record

ArticleJournal of bacteriology2007

EbpR is important for biofilm formation by activating expression of the endocarditis and biofilm-associated pilus operon (ebpABC) of Enterococcus faecalis OG1RF.

Agathe Bourgogne, Kavindra V Singh, Kristina A Fox, Kathryn J Pflughoeft, Barbara E Murray, Danielle A Garsin

Abstract read
In one paragraph

Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Contact dependent suppression ofbioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. Insights into ecology, pathogenesis, and biofilm formation ofMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  5. Article
  6. Review
  7. c-di-AMP Is Essential for the Virulence ofInfection and immunity · 2021
    Article
  8. Article
  9. CRISPR-Virulence · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Novel Molecular Insights about Lactobacillar Sortase-Dependent Piliation.International journal of molecular sciences · 2017
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Agathe BourgogneDivision of Infectious Diseases, Department of Medicine, Center for the Study of Emerging and Re-emerging Pathogens, MSB 2.112, University of Texas Medical School, 6431 Fannin St., Houston, TX 77030, USA.
Kavindra V Singh
Kristina A Fox
Kathryn J Pflughoeft
Barbara E Murray
Danielle A Garsin

Funding

ALTERNATIVE APPROACHES FOR E FAECALIS INFECTIONSR37AI047923 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MURRAY, BARBARA E · 2000 to 2009
$4.0M
NIAID NIH HHS R37 AI047923NIAID NIH HHS R37 AI47923
6 · The paper itself

Abstract

We identify ef1090 (renamed ebpR) and show its importance for the transcriptional regulation of expression of the Enterococcus faecalis pilus operon, ebpABC. An ebpR deletion (DeltaebpR) mutant was found to have reduced ebpABC expression with loss of pilus production and a defect in primary adherence with, as a consequence, reduced biofilm formation.

Indexed as

Gene Expression Regulation, BacterialOperonBacterial AdhesionBacterial ProteinsBiofilmsEnterococcus faecalisFimbriae, BacterialGene DeletionTranscription FactorsBacterial ProteinsTranscription Factors

Identifiers

PMID17586623
PMCPMC1951926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.