ArticleEuropean journal of pharmacology2007
The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder.
Article in European journal of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 39 citations in OpenAlex.
- Lipoxin AbioRxiv : the preprint server for biology · 2024Article
- Endocannabinoids in Bladder Sensory Mechanisms in Health and Diseases.Frontiers in pharmacology · 2021Review
- Potential therapeutic value of transient receptor potential channels in male urogenital system.Pflugers Archiv : European journal of physiology · 2018Review
- TRPA1-dependent regulation of bladder detrusor smooth muscle contractility in normal and type I diabetic rats.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2016Article
- A new and automated method for objective analysis of detrusor rhythm during the filling phase.World journal of urology · 2014Article
- Nitro-oleic acid targets transient receptor potential (TRP) channels in capsaicin sensitive afferent nerves of rat urinary bladder.Experimental neurology · 2011Article
- HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Excitation of cutaneous C nociceptors by intraplantar administration of anandamide.Brain research · 2009Article
- TRPV1: on the road to pain relief.Current molecular pharmacology · 2008Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The contractile responses to capsaicin and anandamide, exogenous and endogenous agonists for transient receptor potential vanilloid receptor 1 (TRPV1), respectively, were investigated in muscle strips isolated from the rat urinary bladder. Capsaicin and anandamide produced concentration-dependent contractions of the muscle strips. The contractile response induced by capsaicin disappeared within approximately 20 min. In contrast, anandamide produced contractile responses lasting at least for 30 min. Capsaicin produced additive contractile responses in anandamide-treated muscle strips. The contractile response to anandamide was attenuated, but not abolished in strips desensitized by capsaicin. The response to capsaicin was abolished in the presence of a TRPV1 antagonist, N-(4-tertiarybutylphenyl)-4-(3-chlorphyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC), but not altered in the presence of either tetrodotoxin, atropine or indomethacin. In the presence of SR140333, a tachykinin NK(1) receptor antagonist or SR48968, an NK(2) receptor antagonist, the response to capsaicin was attenuated. The response to anandamide was partially attenuated in the presence of ONO8130, a prostanoid EP(1) receptor antagonist, URB597, a fatty-acid amide hydrolase inhibitor, BCTC, SR140333 or SR48968, and almost completely abolished by indomethacin. Neither tetrodotoxin, atropine, a cannabinoid CB(1) receptor antagonist, AM251, nor a cannabinoid CB(2) receptor antagonist, AM630, had any effect on the response to anandamide. These results indicate that capsaicin produces muscle contractions by stimulating the TRPV1 receptor, followed by release of neuropeptides that can activate tachykinin NK(1) and/or NK(2) receptors in the bladder and that the contractile response to anandamide is mediated at least in part by activation of prostanoid EP(1) receptors due to production of prostaglandins in addition to TRPV1 receptor activation.
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