Trial reportThe Journal of pediatrics2007
Neurodevelopmental outcomes of premature infants with severe respiratory failure enrolled in a randomized controlled trial of inhaled nitric oxide.
Trial report in The Journal of pediatrics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Follow-up Visit of High Risk Infants
Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.The Cochrane database of systematic reviews · 2020Pooled it
- Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.The Cochrane database of systematic reviews · 2017Pooled it
- Inhaled nitric oxide for respiratory failure in preterm infants.The Cochrane database of systematic reviews · 2017Pooled it
- Prenatal Administration of Betamethasone and Neonatal Respiratory Distress Syndrome in Multifetal Pregnancies: A Randomized Controlled Trial.Current clinical pharmacology · 2020Trial
- Milrinone Pharmacokinetics and Pharmacodynamics in Neonates with Persistent Pulmonary Hypertension of the Newborn.American journal of perinatology · 2017Trial
- Reader variability in the use of diagnostic terms to describe white matter lesions seen on cranial scans of severely premature infants: the ELGAN study.Journal of clinical ultrasound : JCU · 2010Trial
- Two-year neurodevelopmental outcomes of ventilated preterm infants treated with inhaled nitric oxide.The Journal of pediatrics · 2010Trial
- Inhaled nitric oxide in infants >1500 g and <34 weeks gestation with severe respiratory failure.Journal of perinatology : official journal of the California Perinatal Association · 2007Trial
- Association between glycated hemoglobin and the risk of neonatal respiratory distress syndrome in preterm premature rupture of membranes pregnancies.Scientific reports · 2024Article
- SIRT1 alleviates insulin resistance and respiratory distress in late preterm rats by activating QKI5-mediated PPARγ/PI3K/AKT pathway.Cell cycle (Georgetown, Tex.) · 2023Article
- Efficacy of inhaled nitric oxide in preterm infants ≤ 34 weeks: a systematic review and meta-analysis of randomized controlled trials.Frontiers in pharmacology · 2023Review
- Early neurodevelopmental follow-up in the NICHD neonatal research network: Advancing neonatal care and outcomes, opportunities for the future.Seminars in perinatology · 2022Article
- Neurodevelopmental and Growth Outcomes of Extremely Preterm Infants with Short Bowel Syndrome.The Journal of pediatrics · 2021Article
- Early Hypoxic Respiratory Failure in Extreme Prematurity: Mortality and Neurodevelopmental Outcomes.Pediatrics · 2020Article
- Mortality among infants with evolving bronchopulmonary dysplasia increases with major surgery and with pulmonary hypertension.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Diagnostic Approach to Pulmonary Hypertension in Premature Neonates.Children (Basel, Switzerland) · 2017Review
- Inhaled nitric oxide therapy for pulmonary disorders of the term and preterm infant.Seminars in perinatology · 2016Review
- Inhaled nitric oxide in preterm infants: An updated meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Review
- Can nitric oxide-based therapy prevent bronchopulmonary dysplasia?Clinics in perinatology · 2012Review
- CO and NO pulmonary diffusing capacity during pregnancy: Safety and diagnostic potential.Respiratory physiology & neurobiology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 1 institution in 1 country.
Funding
Abstract
objectivesWe hypothesized that inhaled nitric oxide (iNO) would not decrease death or neurodevelopmental impairment (NDI) in infants enrolled in the National Institute of Child Health and Human Development Preemie iNO Trial (PiNO) trial, nor improve neurodevelopmental outcomes in the follow-up group. STUDY
designInfants <34 weeks of age, weighing <1500 g, with severe respiratory failure were enrolled in the multicenter, randomized, controlled trial. NDI at 18 to 22 months corrected age was defined as: moderate to severe cerebral palsy (CP; Mental Developmental Index or Psychomotor score Developmental Index <70), blindness, or deafness.
resultsOf 420 patients enrolled, 109 who received iNO (52%) and 98 who received placebo (47%) died. The follow-up rate in survivors was 90%. iNO did not reduce death or NDI (78% versus 73%; relative risk [RR], 1.07; 95% CI, 0.95-1.19), or NDI or Mental Developmental Index <70 in the follow-up group. Moderate-severe CP was slightly higher with iNO (RR, 2.41; 95% CI, 1.01-5.75), as was death or CP in infants weighing <1000 g (RR, 1.22; 95% CI, 1.05-1.43).
conclusionsIn this extremely ill cohort, iNO did not reduce death or NDI or improve neurodevelopmental outcomes. Routine iNO use in premature infants should be limited to research settings until further data are available.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.