ArticleDevelopmental biology2007
Drosophila TRAP230/240 are essential coactivators for Atonal in retinal neurogenesis.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- An E3 ubiquitin ligase, cullin-4 regulates retinal differentiation in Drosophila eye.Genesis (New York, N.Y. : 2000) · 2020Article
- A Functional Analysis of theG3 (Bethesda, Md.) · 2020Article
- The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway.The Journal of biological chemistry · 2014Article
- Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers.Developmental biology · 2014Article
- Dosage changes of MED13L further delineate its role in congenital heart defects and intellectual disability.European journal of human genetics : EJHG · 2013Article
- Cyclin-dependent kinase 8 regulates mitotic commitment in fission yeast.Molecular and cellular biology · 2012Article
- Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: the lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules.Developmental biology · 2012Article
- Article
- Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation.Development (Cambridge, England) · 2011Article
- Identification of novel regulators of atonal expression in the developing Drosophila retina.Genetics · 2008Article
- Context dependence of proneural bHLH proteins.Current opinion in genetics & development · 2008Review
- Specificity of Atonal and Scute bHLH factors: analysis of cognate E box binding sites and the influence of Senseless.Genes to cells : devoted to molecular & cellular mechanisms · 2008Article
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5 authors.
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Abstract
The TRAP (thyroid hormone receptor associated proteins)/Mediator complex serves as a transcriptional coactivator. In Drosophila, Kohtalo (Kto) and Skuld (Skd), homologs of TRAP subunits, TRAP230 and TRAP240, respectively, are necessary for eye development. However, the transcriptional activators that require Kto and Skd have not been identified. Here we provide evidence that Kto and Skd are essential for the function of transcription factor Atonal (Ato) in spatial patterning of proneural clusters in the morphogenetic furrow. In the absence of Kto/Skd, Ato fails to induce its inhibitory target events such as EGFR signaling and Scabrous expression that result in ectopic Ato expression in the space between proneural groups. Kto/Skd are also required for positive Ato functions to induce Ato targets such as Ato itself and Senseless within the proneural clusters. We also show that Skd forms a protein complex with Ato in vivo. These data suggest that Kto/Skd act as essential coactivators for Ato expression during early retinal neurogenesis.
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