Trial reportThe Journal of nutrition2007
Nutrient ingestion, protein intake, and sex, but not age, affect the albumin synthesis rate in humans.
Trial report in The Journal of nutrition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Assessment of protein requirement in octogenarian women with use of the indicator amino acid oxidation technique.The American journal of clinical nutrition · 2014Trial
- Influence of megestrol acetate on nutrition, inflammation and quality of life in dialysis patients.International urology and nephrology · 2012Trial
- The skeletal muscle transcript profile reflects accommodative responses to inadequate protein intake in younger and older males.The Journal of nutritional biochemistry · 2010Trial
- Metabolic benefits of rivaroxaban in non-valvular atrial fibrillation patients after radiofrequency catheter ablation.Journal of Zhejiang University. Science. BTrial
- Physical Indicators and Cutoff Values Associated with Improvement in Sarcopenia in Older Adults Undergoing Rehabilitation.Journal of frailty, sarcopenia and falls · 2026Article
- Association between nutritional‑inflammatory status and diabetic retinopathy in adults with diabetes: insights from a US population‑based survey and a Chinese hospital‑based clinical cohort.Frontiers in endocrinology · 2026Article
- Aging and liver health: liver chemistries and associated factors in community-dwelling older adults.BMC geriatrics · 2025Article
- Gender differences in systemic inflammatory and nutritional index following radical surgery for advanced gastric cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- Incidence and Predictors of Mortality among Community-Dwelling Older Adults in Malaysia: A 5 Years Longitudinal Study.International journal of environmental research and public health · 2022Article
- Review
- Urea-to-Albumin Ratio and In-Hospital Mortality in Severe Pneumonia Patients.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Article
- Hypoalbuminemia - An Indicator of the Severity and Prognosis of COVID-19 Patients: A Multicentre Retrospective Analysis.Infection and drug resistance · 2021Article
- Nutrition Status Related to Clinical Improvement in AFB-Positive Pulmonary Tuberculosis Patients in Primary Health Centres in Medan, Indonesia.Open access Macedonian journal of medical sciences · 2019Article
- Increased Ratio of Non-mercaptalbumin-1 Among Total Plasma Albumin Demonstrates Potential Protein Undernutrition in Adult Rats.Frontiers in nutrition · 2018Article
- Potential Role of Amino Acid/Protein Nutrition and Exercise in Serum Albumin Redox State.Nutrients · 2017Review
- Impact of serum nutritional status on physical function in african american and caucasian stroke survivors.Stroke research and treatment · 2014Article
- Age and sex affect protein metabolism at protein intakes that span the range of adequacy: comparison of leucine kinetics and nitrogen balance data.The Journal of nutritional biochemistry · 2013Article
- Physiology of aging among healthy, older bottlenose dolphins (Tursiops truncatus): comparisons with aging humans.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2011Article
- A specific protein-enriched enteral formula decreases cortisolemia and improves plasma albumin and amino acid concentrations in elderly patients.Nutrition & metabolism · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The aim of this study was to assess the effects of nutrient ingestion, dietary protein intake, age, and sex on the fractional synthesis rate (FSR) of albumin. Thirty-six healthy free-living individuals (8 females and 10 males aged 21-43 y and 9 females and 9 males aged 63-79 y) completed three 18-d periods of controlled feeding with protein intakes of 125% (P125, 1.00 g protein x kg(-1) x d(-1)), 94% (P94, 0.75 g protein x kg(-1) x d(-1)), and 63% (P63, 0.50 g protein x kg(-1) x d(-1)) of the recommended dietary allowance. On d 12 of each trial, postabsorptive (PA) serum albumin concentration was determined and PA and postprandial (PP) albumin FSR were estimated from the rate of l-[1- 13C] leucine incorporation into plasma albumin during an 8-h infusion. There were no age-related differences in PA and PP albumin FSR. Albumin FSR was higher PP than PA (P < 0.0001), and the increase in albumin FSR from PA to PP was smaller as dietary protein intake decreased from P125 to P94 and P63 (P < 0.05). Independent of protein intake, males had a higher albumin FSR (P < 0.05) and a greater increase in albumin FSR with feeding (P < 0.05). There was no age or dietary protein effect on serum albumin concentrations, but males had higher albumin concentrations than females (P < 0.0001). These results show that older persons are responsive to nutrient ingestion and dietary protein-related changes in albumin FSR. The greater albumin synthesis rate in males might contribute to a higher albumin concentration set point.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.